Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with acute myeloid leukaemia (AML) according to specific 2022 medical guidelines, whose leukaemia showed intermediate- or high-risk chromosome abnormalities, and whose disease went into complete remission (no detectable cancer) after a stem cell transplant from a donor.
• People whose leukaemia remained in complete remission after the transplant.
• People who are enrolling between 60 and 100 days after their transplant.
• People aged 18 to 75 years.
• People who are in good general physical condition, able to carry out normal daily activities with little or no limitation (confirm with trial site for exact fitness level required).
• People whose kidney function blood test results are within an acceptable range (below 1.5 times the upper limit of normal for creatinine).
• People whose liver function results are within acceptable ranges — specifically, direct bilirubin below 1.5 mg/dL (with an exception for those with a condition called Gilbert's syndrome), and liver enzyme levels (ALT and AST) below 2.5 times the upper limit of normal.
• People who are able to understand the trial information and sign a written consent form.

Who may not be able to join:

• People who have received any other experimental or investigational medications after their transplant.
• People whose leukaemia has a specific genetic change called an FLT3 mutation.
• People whose leukaemia has spread to the brain or spinal cord.
• People experiencing uncontrolled moderate-to-severe graft-versus-host disease (a condition where donor cells attack the body) after their transplant.
• People with an active infection that is not currently under control.
• People with a known or suspected allergy or sensitivity to the study drug (Chidamide) or any of its ingredients.
• People with uncontrolled heart failure or other serious ongoing health conditions that, in the treating doctor's judgement, would make participation unsafe or interfere with assessing the treatment.
• People who are pregnant or breastfeeding.
• People who have any other condition that, in the treating doctor's judgement, would make participation unsuitable.

Important: Always verify eligibility with the trial site directly before applying.