Early Phase 1 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 70 years old (both ages included), of any gender or racial background
• People whose doctors estimate they are expected to live for more than 12 weeks
• People with a general health and activity level rated at 0, 1, or 2 on a standard medical scale called the ECOG scale, meaning they are able to carry out at least some daily activities (confirm with trial site)
• People diagnosed with a blood cancer that has come back or stopped responding to treatment — specifically non-Hodgkin lymphoma (NHL) or acute lymphoblastic leukemia (ALL) — where the cancer cells test positive for a protein called CD19, and whose diagnosis meets recognised treatment guidelines (NCCN)
• People whose liver, kidney, heart, and lung function test results meet the trial's required levels
• People whose blood test results show certain minimum levels of immune and blood cells, including lymphocytes, platelets, and a specific type of T cell (confirm exact values with trial site)
• People who have a body temperature of 38°C or below in the 24 hours before receiving the trial treatment, and who do not have a significant active infection at that time
• People who have not received higher-dose steroid medications or other immune-suppressing drugs in the 5 days before receiving the trial treatment

Who may not be able to join:

• People who, in the trial doctor's judgement, are likely to need long-term use of immune-suppressing medications
• People who have had a stroke or seizure in the six months before signing the trial consent form
• People who have another type of cancer in addition to the blood cancer being studied (an exception may be considered for very early-stage, non-invasive cancers — confirm with trial site)
• People who test positive for certain infections, including active Hepatitis B, Hepatitis C, HIV, Cytomegalovirus (CMV), or Syphilis (confirm which specific test results apply with trial site)
• People with serious heart conditions, including unstable chest pain (angina), a heart attack within the past 6 months, significant heart failure, or severe irregular heartbeat
• People who, in the trial doctor's judgement, have unstable serious conditions affecting the liver, kidneys, or metabolism that require ongoing medication
• People with a chronic, progressively worsening neurological (brain or nerve) condition
• People who have not yet fully recovered from side effects caused by a previous cancer treatment
• People who have an active infection that requires treatment throughout the whole body, or an infection that is not under control (people with mild urinary or upper respiratory infections may still be considered — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.