Phase 2 Alopecia Areata Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be generally healthy, based on a review of your medical history, a physical exam, and a heart tracing test (ECG)
• Your blood tests, urine tests, and clotting tests must all come back within normal ranges
• Your body mass index (BMI) must be between 18 and 32, and you must weigh more than 60 kg (about 132 lbs)
• Both men and women must be willing to avoid pregnancy for the entire duration of the trial
• You must be able to and willing to sign a consent form agreeing to take part
• You must have no signs or symptoms of tuberculosis (TB), either active or hidden

For people joining with hair loss (AGA) specifically:

• You must have a confirmed diagnosis of a specific pattern of hair loss, rated on a recognised medical scale (Norwood-Hamilton Scale III vertex to V for men, or Ludwig Scale I-3, I-4, II-1, or II-2 for postmenopausal women)
• You must be willing to have the hair in the study area clipped for analysis and avoid using colour or pigment products on your scalp
• You must be willing to keep roughly the same hair length at every study visit
• For postmenopausal women: your hair loss must have been present for at least 12 months, with no sudden or rapid worsening in the 6 months before joining

Who may not be able to join:

• You have a history of cancer, unless it was basal cell skin cancer or a cervical condition that was fully treated with no return for at least 90 days before the trial
• You have a history of liver disease or abnormal liver function test results
• Your blood pressure or heart rate falls outside a certain safe range at screening (confirm with trial site)
• You test positive for HIV, hepatitis B, or hepatitis C
• You have recently donated blood
• You have a significant psychiatric (mental health) condition
• You are pregnant, breastfeeding, or planning to become pregnant during the study
• You have a history of postnatal depression, mood changes around menopause, or symptoms related to estrogen withdrawal

For people joining with hair loss (AGA) specifically:

• You have used certain hair loss treatments recently, including minoxidil (topical within 3 months, oral within 6 months), finasteride within 6 months, or dutasteride within 12 months before screening
• You have used certain weight-loss or diabetes medications (such as semaglutide or tirzepatide) within 3 months before screening
• You have had a hair transplant or major scalp procedure, or have one planned during the study
• You have used hair extensions, wigs, weaves, or similar artificial hair products within 30 days before screening or during the study
• You have a significant skin condition affecting your scalp that could interfere with hair assessments

Important: Always verify eligibility with the trial site directly before applying.