Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given voluntary written consent to participate
• Adults aged 18 to 70 years (inclusive), of any sex
• People with glioblastoma (a type of brain tumour, grade 4, IDH wild-type) that has come back or continued to grow, confirmed through tissue or molecular testing according to the 2021 WHO brain tumour classification guidelines
• People whose tumour tissue shows a certain level of specific proteins called CD44 or CD133, confirmed by laboratory staining of tumour tissue — this applies only to the Phase II part of the trial (confirm with trial site)
• People with at least one measurable area of tumour that meets specific imaging criteria and measures 3 cm or less at its longest point
• People who have already received radiation therapy and/or chemotherapy with temozolomide or bevacizumab
• People whom the treating doctor has confirmed are suitable for a specific type of brain surgery involving a fluid drainage system and a small device called an Ommaya reservoir implanted under the scalp

Who may not be able to join:

• People with a history of severe allergies or allergic reactions, including to cell-based products
• People who have received certain cancer treatments within a specified period before a blood collection procedure — including biological therapies within 6 weeks, radiotherapy or surgery within 4 weeks, chemotherapy or immune-modulating drugs within 2 weeks, or certain traditional Chinese herbal medicines with anticancer properties within 1 week
• People whose side effects from previous cancer treatments have not sufficiently resolved (side effects must have improved to a mild level or lower, with some exceptions such as hair loss or skin changes)
• People whose tumour has spread to the brainstem or spinal cord
• People with serious neurological conditions other than the brain tumour, such as meningitis, encephalitis, uncontrolled epilepsy, myasthenia gravis, or similar conditions
• People with a primary immune system deficiency, autoimmune diseases requiring ongoing medication (such as Crohn's disease, rheumatoid arthritis, or lupus), or a past history of autoimmune diseases affecting the nervous system (such as multiple sclerosis or Parkinson's disease)
• People currently receiving or requiring long-term use of immune-suppressing medications, with limited exceptions for low-dose or short-term steroid use
• People who have previously had a bone marrow or organ transplant, or who are currently waiting for one
• People with certain active infections, including active hepatitis B, active hepatitis C, syphilis, or HIV
• People who have previously participated in any gene therapy or cell therapy trial
• People who are pregnant or currently breastfeeding
• People with a history of another cancer (other than glioma) within the past 5 years, with some exceptions for certain low-risk, well-treated cancers as determined by the treating doctor

Important: Always verify eligibility with the trial site directly before applying.