Phase 3 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be willing and able to sign a consent form agreeing to take part in the study.
• You must be between 18 and 55 years old (inclusive) at the time of signing the consent form.
• You must have been diagnosed with multiple sclerosis (MS) using a recognised set of medical guidelines called the McDonald criteria (2017 version).
• You must have the relapsing-remitting type of MS, where symptoms come and go in episodes.
• Your MS disability level must fall within a certain range on a standard scoring scale (confirm with trial site for exact details).
• You must have had at least one MS relapse (flare-up) in the past 12 months, OR two relapses in the past 24 months, OR at least one active area seen on a specific type of brain scan (MRI) plus one relapse in the past 24 months.
• A blood test must show that you have had a previous chickenpox infection or vaccination (presence of certain antibodies).
• Your MS symptoms must have been stable for at least 30 days before signing the consent form.
• You must be willing to stop taking any current MS medications from the day you receive your first dose of the trial drug and throughout the study.
• You must be able to follow all the steps and procedures required by the study, in the opinion of the study doctor.
• You and your partner (if they could become pregnant) must be willing to use reliable contraception from signing the consent form, throughout the study, and for 5 months after your last dose of the trial drug.

Who may not be able to join:

• You have the primary progressive or secondary progressive type of MS.
• You have had MS for more than 10 years and have a very low disability score on the standard MS scale (confirm with trial site for exact details).
• You have a particularly severe or aggressive form of MS (confirm with trial site).
• You have another medical condition that could make it difficult to accurately assess your MS symptoms.
• You are unable to have a good-quality MRI scan, or you have a reason why you cannot have an MRI or be given the contrast dye used during the scan.
• You have another condition that requires you to take steroid tablets or immune-suppressing medicines during the study (other than for MS).
• You have a history of a serious brain infection called progressive multifocal leukoencephalopathy (PML).
• You have an active or worsening infection found during the screening process that could put your safety at risk during the study.
• You have other health conditions that could affect the assessment of your MS or significantly increase your risk of side effects during the study.
• You have a known problem with alcohol or drug addiction, or you are currently showing signs of this.
• You have a history of severe depression, or your score on a standard depression questionnaire is at or above a certain level at the time of screening.
• You have had a cancer diagnosis within the past 5 years before screening.
• You have a diagnosis of HIV, hepatitis B, or hepatitis C.
• It is not possible to take blood from a vein for the study tests.
• You are pregnant, breastfeeding, planning to become pregnant, or planning to donate eggs during the study or within 5 months after your last dose of the trial drug.
• You have had a severe allergic or life-threatening reaction to certain types of antibody-based medicines in the past (confirm with trial site for exact details).
• You have previously taken certain medicines or received certain treatments that are not allowed in this study (confirm with trial site for the full list).
• Your blood test results fall outside the ranges considered acceptable for this study (confirm with trial site for exact details).

Important: Always verify eligibility with the trial site directly before applying.