Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed a consent form agreeing to take part in the study.
• People aged 18 or older.
• People who are being considered for surgery to fully remove a kidney, with or without removal of nearby lymph nodes.
• People diagnosed with high-risk kidney cancer meeting at least one of the following: cancer that has grown into surrounding tissue or lymph nodes but not spread elsewhere (stage cT3-4); a lymph node visible on scans measuring more than 1cm; cancer that had spread to other parts of the body but was treated and shows no remaining signs of disease; or cancer that has grown into nearby organs on scans. Alternatively, people meeting at least two of these features: cancer growing into the main kidney vein or a large vein leading to the heart; aggressive tumour characteristics under the microscope; a tumour 10cm or larger; or blood in urine and/or local symptoms (confirm with trial site).
• People whose cancer can be measured on scans according to standard criteria (RECIST v1.1).
• People who are generally well enough to carry out light activity and care for themselves (ECOG score of 0 or 1).
• People whose blood, kidney, and liver results are within an acceptable range.
• People of childbearing potential who agree to use effective contraception throughout the study.

Who may not be able to join:

• People who have previously had radiotherapy, chemotherapy, major surgery, or targeted drug treatment for kidney cancer.
• People who currently have another active cancer (except certain well-controlled cancers not expected to affect survival within two years).
• People whose medical team has determined that a partial kidney removal or tumour ablation procedure would be more appropriate.
• People whose scans suggest that nearby lymph nodes cannot be surgically removed.
• People with certain hereditary kidney cancer conditions (confirm with trial site).
• People diagnosed with any other active cancer within the past five years.
• People with an active or past autoimmune disease (a condition where the immune system attacks the body).
• People who have taken immune-suppressing medications within two weeks before joining the study.
• People with poorly controlled heart conditions or significant related symptoms.
• People with blood clotting problems or a tendency to bleed.
• People with active digestive conditions that carry a risk of bleeding or perforation.
• People with a history of significant bleeding or serious blood clot events within certain timeframes (confirm with trial site).
• People with a current infection or an unexplained fever above 38.5°C.
• People who had an abdominal fistula, bowel perforation, or abscess within the four weeks before joining.
• People with a history of lung scarring, interstitial lung disease, or severely reduced lung function.
• People with a known immune deficiency condition or active hepatitis.
• People who have taken part in another clinical trial within the past month.
• People with a known history of drug or alcohol addiction.
• People who are unable or unwilling to cover any required out-of-pocket costs for examinations and treatment.
• People with any other condition that the trial doctor believes could affect their safety or the conduct of the study.

Important: Always verify eligibility with the trial site directly before applying.