Phase 3 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Group A — Relapsing MS (RMS):

• People aged 18 to 55 years old at the time of signing the consent form.
• People who have been diagnosed with relapsing MS, confirmed using the 2017 revised McDonald diagnostic guidelines.
• People whose disability level, measured by a standard MS scoring tool, is at or below a certain threshold at the first study visit (confirm with trial site).
• People who have had at least one MS relapse in the past year, OR two relapses in the past two years, OR at least one area of active inflammation visible on an MRI scan in the past year.

Group B — Non-relapsing Secondary Progressive MS (nrSPMS):

• People aged 18 to 60 years old at the time of signing the consent form.
• People who were previously diagnosed with relapsing-remitting MS under the 2017 revised McDonald guidelines, and who now have a diagnosis of secondary progressive MS.
• People whose MS disability has been documented to have worsened during the 12 months before joining the study.
• People who have had no MS relapses for at least 24 months.
• People whose disability score on a standard MS scale falls within a specific range at the first study visit (confirm with trial site).

All participants:

• People who are able to use an acceptable form of contraception as required by local guidelines for clinical trial participants.

Who may not be able to join:

• People who have been diagnosed with primary progressive MS under the 2017 revised McDonald criteria.
• People who have a current infection, a recent fever within 28 days before the screening visit, or a history of conditions that may increase the risk of serious infection.
• People who have a history of a psychiatric condition or substance misuse.
• People who have a history of, or are considered at significant risk of, blood clots, heart attack, stroke, or a related clotting condition, or who require blood-thinning medication.
• People who have low levels of certain protective proteins in the blood (immunoglobulins) at screening, or who have a history of a condition causing low immunoglobulin levels.
• People who have, or have had, another condition whose symptoms can look similar to MS symptoms.
• People who are unable to have an MRI scan for any reason.

Important: Always verify eligibility with the trial site directly before applying.