Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to sign a consent form agreeing to take part in the study.
• You are 18 years old or older.
• You are generally well enough to carry out light activity or normal daily tasks (your doctor can confirm this based on a standard fitness scale).
• Your doctor expects you to live for at least 12 months.
• You have been confirmed by a biopsy or similar test to have thyroid cancer that has spread to lymph nodes in the neck, the cancer has come back or spread after a previous thyroid surgery with lymph node removal, and the number of affected lymph nodes on one side of the neck is 5 or fewer, with none larger than 3 cm.
• You are not a good candidate for repeat surgery, or you have declined repeat surgery, or radioactive iodine treatment has not worked for you or you have declined it.
• Your blood counts, kidney function, liver function, blood clotting, and heart function are all within acceptable ranges as determined by blood and urine tests (confirm with trial site for specific values).
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 3 days before starting treatment and agree to use reliable contraception from the start of the study until 6 months after your last dose.
• If you are a man who has not had a vasectomy and your partner could become pregnant, you must agree to use reliable contraception from the start of the study until 6 months after your last dose.
• You are willing and able to attend all required visits and follow all study procedures.

Who may not be able to join:

• You have a history of serious bleeding problems or blood clotting disorders, or you have had significant bleeding (such as from the gut or lungs) in the month before treatment, or you have been on blood-thinning medication in the 10 days before starting treatment.
• You have a history of serious heart conditions such as heart muscle inflammation, heart failure, dangerous heart rhythm problems, or you have been hospitalised for a heart-related issue in the past 12 months.
• You are unable to cooperate with treatment or cannot safely receive general anaesthesia.
• Your cancer has spread to parts of the body outside the neck area.
• The affected lymph nodes are in a specific deep area of the neck known as "level VII" (confirm with trial site).
• You have received radioactive iodine therapy in the past 6 months.
• You have a known allergy to the contrast dyes used in ultrasound or CT scans, or you cannot have these types of imaging for any reason.
• You have had neck surgery, local ablation treatment, chemotherapy, or immunotherapy/targeted therapy in the past 3 months.
• In the doctor's judgement, the treatment needles cannot be placed safely in your neck.
• You have metal implants such as plates or screws, or a permanently fitted catheter in your neck area that could interfere with the treatment.
• You currently have another untreated cancer, or you have had a cancer diagnosis within the past 5 years (except for certain minor skin cancers or early-stage cervical changes — confirm with trial site).
• You are currently taking part in another clinical trial.
• You have a known history of psychiatric illness, alcohol misuse, or illegal drug use.
• You have had major surgery or a serious injury in the 30 days before treatment, or you are planning major surgery within 30 days after starting treatment.
• You have had certain serious digestive or stomach problems (such as internal bleeding, bowel obstruction, or unhealed wounds) in the past 6 months, or a recent flare-up of a chronic lung condition in the past month.
• You have had a serious blood clot, stroke, mini-stroke, or severe high blood pressure episode in the past 6 months, or your blood pressure is currently very high even with medication.
• You have any other medical condition, ongoing treatment, or abnormal test result that the study doctor believes could affect your safety or the reliability of the study results.
• You have a non-cancer illness or cancer-related condition that puts you at high medical risk, such as significant unintended weight loss or abnormal blood counts (confirm with trial site for details).
• The study doctor has any other concern that makes participation unsuitable for you.

Important: Always verify eligibility with the trial site directly before applying.