Phase 1 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are generally in good health, as confirmed by a medical check-up
• You weigh at least 50 kg (about 110 lbs) if you are male, or at least 45 kg (about 99 lbs) if you are female
• Your Body Mass Index (BMI — a measure of body weight relative to height) is between 18.0 and 28.0
• Both men and women are welcome to apply
• You are of Chinese ancestry, were born in mainland China, Hong Kong, or Taiwan, and have lived outside those places for less than 10 years at the time of screening
• You are of Japanese ancestry, were born in Japan, have two Japanese parents and four Japanese grandparents, and have lived outside Japan for less than 10 years at the time of screening
• You identify as being of White/European ancestry (from the original peoples of Europe), regardless of where you currently live, and have two parents and four grandparents of White/European ancestry

Who may not be able to join:

• You have a history of conditions that could significantly affect how your body absorbs, processes, or removes medicines (confirm with trial site)
• You have a current or long-term history of liver or bile duct disease — except for a condition called Gilbert's syndrome or gallstones that cause no symptoms
• You have a history of pancreas injury, pancreatitis, or other pancreatic disease; Type 1 Diabetes; or serious complications from Type 2 Diabetes such as severe stomach-emptying problems or nerve damage
• Your blood pressure is too high — specifically, the top number is 140 or above, or the bottom number is 90 or above
• You have a history of bone conditions such as osteoporosis, low bone density (osteopenia), or softening of the bones (osteomalacia)
• You have had any type of cancer in the past 5 years, except for a specific minor form of skin cancer (localised basal cell carcinoma)
• Certain liver-related blood test results are above acceptable levels (confirm with trial site)
• You have a known bleeding disorder
• You have a history of immune system diseases, or you have tested positive for HIV
• Your heart's electrical activity (measured by an ECG) shows a reading that is too high — 450 msec or above for men, or 470 msec or above for women
• You are currently taking cholesterol-lowering (statin) medications or blood pressure medications, unless you have been on a stable dose for at least 3 months
• You have taken part in another drug trial recently, or are currently taking an experimental drug (confirm with trial site for exact timeframes)
• You have ever received a treatment involving a substance called FGF21 or a similar drug
• You plan to take or are currently taking any over-the-counter, prescription, or herbal medicines within 7 days before your dose and throughout the study
• You have received a live vaccine within 14 days before dosing, or a non-live vaccine within 7 days before dosing
• You are currently enrolled in or have taken part in another clinical trial within the last 30 days
• You have tested positive for Hepatitis B or Hepatitis C at screening or within 3 months before the study
• You have tested positive for drugs or alcohol in a pre-study screening test

Important: Always verify eligibility with the trial site directly before applying.