Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with extensive-stage small cell lung cancer (a type of lung cancer that has spread), confirmed through a tissue or cell sample.
• People who have not yet received any systemic (whole-body) treatment for this type of lung cancer.
• People who have at least one tumour that can be measured on a scan, according to standard research measurement guidelines.
• People aged between 18 and 75 years.
• People whose general physical health and ability to carry out daily activities falls within a certain acceptable range, as assessed by a doctor using a standard scale (confirm with trial site).
• People who are expected to live for at least 3 months.
• People whose blood cell counts, kidney, liver, heart, and clotting functions all meet minimum levels set by the trial (confirm with trial site for the specific values).
• Women who could become pregnant must have a negative pregnancy test within 3 days before starting treatment and must agree to use highly effective contraception throughout the trial.
• Men must agree to use barrier contraception (such as condoms) during the trial.
• People who are willing and able to sign a consent form and follow the study procedures.

Who may not be able to join:

• People who have brain metastases (cancer that has spread to the brain) that are causing symptoms. Those with treated, stable, symptom-free brain metastases for at least one month without the need for steroids may still be considered.
• People who have previously had radiotherapy to the chest area for small cell lung cancer.
• People who have previously been treated with certain types of cancer medicines, including anti-angiogenic drugs (such as anlotinib or bevacizumab) or immune checkpoint therapies targeting PD-1 or PD-L1.
• People who have difficulty swallowing or have had major bowel or stomach surgery that could affect the ability to take oral (swallowed) medication.
• People who have fluid build-up around the lungs, heart, or abdomen that is not under control and requires repeated draining.
• People whose scans show that the tumour is growing into major blood vessels, or who are considered at high risk of serious bleeding by the treating doctor.
• People with a history of significant bleeding problems, including coughing up more than roughly one tablespoon of blood per day in the past 3 months, or any significant bleeding episode within 4 weeks before joining the trial.
• People who have had major surgery, an open biopsy, or a serious injury within 28 days before joining the trial.
• People who have had a blood clot or stroke (in an artery or vein) within the past 6 months, such as a stroke, deep vein thrombosis, or pulmonary embolism.
• People who have an active autoimmune disease that has required systemic (whole-body) treatment at any point in the 2 years before starting the trial.
• People who have any other medical condition that the treating doctor believes would increase risk or make participation in the trial unsuitable.

Important: Always verify eligibility with the trial site directly before applying.