Phase 3 Long COVID Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old
• You have severe fatigue, as measured by a specific fatigue questionnaire score (confirm with trial site)
• Your fatigue started or got significantly worse after having COVID-19 (based on your own account)
• Your fatigue has been present for at least 3 months after your COVID-19 infection
• You have confirmed you had COVID-19 through a positive PCR test, a positive rapid test (including a home test), or a diagnosis from a doctor or hospital — note that medical records will not be checked to verify this
• You can read and complete questionnaires in Dutch or English
• You are able to take part in video calls
• You are willing and able to give your informed consent to participate
• You agree to allow the trial team to share relevant medical information with your GP and pharmacy if needed for your safety

Who may not be able to join:

• You are taking medication that cannot be stopped and that would interact with the study drug (fluvoxamine)
• You were hospitalised during the acute phase of your COVID-19 illness
• You have a psychiatric or physical condition that could explain your level of fatigue
• You have a neurodegenerative condition such as Parkinson's disease, Multiple Sclerosis, or Alzheimer's disease
• You are currently or have recently had thoughts of suicide (assessed using a standard screening tool)
• You have started taking another medication aimed at treating post-COVID symptoms in the last 2 months
• You are pregnant or are unwilling to use standard contraception during the trial
• You have a heart condition called Brugada syndrome or Long QT syndrome
• You have epilepsy, porphyria, or a history of serious liver problems
• You have a known allergy to fluvoxamine or any ingredients in the placebo
• You currently have known problems with alcohol or drug use
• You have a bleeding disorder or a past history of bleeding stomach or intestinal ulcers or other significant bleeding problems
• You have claustrophobia (this applies to an optional MRI part of the study only)
• You have metal implants in your body (this applies to an optional MRI part of the study only)
• You are unable to lie still for 45 minutes (this applies to an optional MRI part of the study only)
• You have had a significant brain injury, large stroke, or brain abnormalities that could affect scan results (this applies to an optional MRI part of the study only)
• You are unable to travel to Amsterdam UMC in person (this applies to an optional MRI part of the study only)

Important: Always verify eligibility with the trial site directly before applying.