Phase 1 Osteoporosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women aged 45 to 70 years who have gone through menopause, with their last menstrual period no more than 10 years ago
• People who have not used hormone replacement therapy for at least one year before the study begins
• People who currently exercise less than 7 hours per week and are willing to avoid exercise for 24 hours before each blood and stool sample is collected
• People who are willing to take a blackcurrant dietary supplement or a placebo capsule (up to 3 capsules per day, 392mg each)
• People who are willing to stop taking any other dietary supplements for the entire duration of the study
• People who are willing to avoid foods very high in anthocyanins (a type of natural pigment found in dark berries) and fermented dairy products containing certain live bacteria (such as some yoghurts or probiotic products)
• People who are willing to have three blood draws, three stool samples collected, and three bone scans during the study

Who may not be able to join:

• People with a history of heart or cardiovascular disease, osteoporosis, metabolic bone disease, cancer, diabetes, arthritis, or other long-term inflammatory conditions
• People who currently smoke
• People taking prescription medications known to affect bone strength or calcium levels in the body
• People who have taken bone-building agents such as parathyroid hormone, growth hormone, or steroids within 3 months before the study starts
• People taking medications that affect bleeding (such as blood thinners) or people who have a bleeding disorder
• People who drink more than 2 alcoholic drinks per day, or more than 12 drinks per week
• People who have surgery planned during the study period or within 2 weeks after the study ends
• People with a known sensitivity or allergy to rice powder (used in the placebo capsules)
• People who have a medical procedure planned that involves iodine, barium, or nuclear medicine during the study period
• Students or employees of UConn who are taught by, or report directly to, any of the key study staff
• People who are key study personnel themselves, or who are partners, dependents, or close relatives of key study personnel

Important: Always verify eligibility with the trial site directly before applying.