Interstitial Lung Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Children from birth up to 18 years old, of any sex
• Children who have been diagnosed with a condition called LCH (Langerhans cell histiocytosis), confirmed through laboratory testing, and who have not yet received any treatment specifically for LCH
• Children whose LCH affects multiple spots in the bones, OR affects a single bone location in certain sensitive areas of the head (such as around the eyes, ears, or mouth — but not the parietal, occipital, or frontal bones), OR affects a single spot in the spine where it is pressing on the spinal cord
• Children (and their parent or guardian) who are willing to sign a consent form, follow the treatment plan described in the trial, and attend follow-up appointments

Who may not be able to join:

• Children who have other serious underlying health conditions, such as a weakened immune system from birth, heart failure, kidney problems, hepatitis, HIV infection, or who have had an organ transplant
• Children who have a second, separate cancer diagnosis
• Children whose heart electrical activity test (ECG) shows a reading above a certain level before joining the trial (confirm with trial site)
• Children whose eye examination before joining the trial shows certain eye conditions, such as a blocked vein in the eye, a detached layer at the back of the eye, or other significant eye problems
• Children whose LCH has a specific type of genetic change (called a category 3 MEK mutation) — there is a particular list of mutation types that would make a child ineligible (confirm with trial site)
• Children (or their parent/guardian) who are not willing to sign the consent form

Important: Always verify eligibility with the trial site directly before applying.