Thyroid Cancer Trial, Recruiting NCT07376837 Sponsor: University Health Network, Toronto Condition: Thyroid Cancer
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Thyroid Cancer Trial, Recruiting

NCT07376837
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with a specific type of thyroid cancer called papillary thyroid carcinoma, confirmed by a needle biopsy or tissue sample.
  • Your thyroid tumor(s) are each no larger than 2.0 cm (about the size of a small grape) at their widest point.
  • Your cancer has not spread outside the thyroid gland, and there is no sign it has reached nearby lymph nodes or other parts of the body.
  • Your tumor is located a safe distance (more than 2 mm) away from important nearby structures like the windpipe, food pipe, or major blood vessels — or it can be safely treated using a technique that moves those structures out of the way.
  • Your cancer is classified as an early stage (T1b or lower), with no known spread to lymph nodes or distant organs.
  • You are either not healthy enough for surgery due to other medical conditions, or you have chosen not to have surgery.
  • You are 18 years old or older.
  • You are not pregnant at the time of treatment.
  • You are able to understand the study information and agree to take part by signing a consent form.

Who may not be able to join:

  • There is any sign — on scans or physical examination — that your cancer has spread to lymph nodes or other parts of the body such as the lungs or bones.
  • Your tumor has grown beyond the edges of the thyroid gland into surrounding tissue.
  • Your tumor has heavy calcium deposits throughout it.
  • Your tumor is too close (within 2 mm) to important nearby structures and cannot be safely treated, even with techniques to move those structures.
  • You have previously had surgery or any other ablation treatment (such as heat, laser, alcohol, or microwave therapy) on the same tumor being studied.
  • You have been diagnosed with a more aggressive or fast-growing type of thyroid cancer (other than papillary thyroid carcinoma).
  • You are pregnant or breastfeeding when enrolling in the study.
  • You have a condition that affects blood clotting, or you take blood-thinning medications that cannot be safely stopped before the procedure.
  • You have a serious illness that is expected to significantly shorten your life expectancy (less than 5 years).
  • You are unable to attend follow-up appointments or follow the study schedule, or you are not able to make your own medical decisions.
  • You have an implanted electrical device in your body, such as a pacemaker or nerve stimulator.
  • You have an active infection in your neck — including a skin infection or thyroid inflammation — at the time of the planned treatment.
  • You have significant scarring or changes to the structure of your neck from previous neck surgery or radiation therapy that would make the procedure unsafe.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Sangeet Ghai, MD, University Health Network - Toronto General Hospital

Phone: 416-500-5737

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
5 February 2026
Est. completion
31 December 2026

Where this trial is recruiting

🇨🇦 Canada

Primary endpoints

Local Cure Rate of Papillary Thyroid Cancer (PTC) following Radiofrequency; Safety of the RFA procedure

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov