Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 80 years, of any gender
• People who have had surgery to remove the bladder (radical cystectomy), where tissue from the removed bladder will be used to grow laboratory cell cultures called organoids
• People whose bladder cancer has been found to have spread beyond the bladder wall or into nearby lymph nodes (stages pT3–pT4 and/or lymph node-positive), and who need chemotherapy after surgery
• People whose overall health is good enough to tolerate platinum-based chemotherapy (a common type of cancer chemotherapy)
• People with a general health and activity level rated at 0, 1, or 2 on a standard medical scale, meaning they are able to carry out at least some daily activities (confirm with trial site)
• People who are willing and able to follow the study plan, attend check-ups, and report any side effects or changes in health
• People who have understood the study and have signed a consent form agreeing to take part

Who may not be able to join:

• People who experienced serious, life-threatening complications after bladder removal surgery, such as heart problems, kidney failure, breathing failure, liver failure, severe infection, blood clots in the lungs, or major bleeding
• People with a weakened immune system, such as those living with AIDS, or those receiving treatments that suppress the immune system or radiotherapy
• People known to have an allergy to the study drug, similar drugs, or their ingredients, or people who have a history of severe allergic reactions in general
• People who take corticosteroid medicines long-term, or who have a history of drug misuse or dependence
• People who are pregnant, breastfeeding, or planning to become pregnant in the near future
• People whose blood test results fall outside acceptable levels, including low counts of white blood cells, red blood cells, or platelets, abnormal liver or kidney function, or abnormal blood clotting results (confirm with trial site for specific values)
• People who have ever been diagnosed with certain blood or bone marrow conditions, including myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML)
• People with a known history of neurological or psychiatric conditions, such as epilepsy or dementia
• People with other serious health conditions that could put them at risk or affect their ability to complete the study, such as severe high blood pressure, diabetes, or thyroid disorders
• People with other serious illnesses that require additional treatment or that have significantly abnormal test results
• People whose personal or family circumstances could affect their safety or the collection of study data and samples
• People with ongoing or uncontrolled health conditions, including active infections needing treatment, heart failure with symptoms, unstable chest pain, or irregular heartbeat
• People considered by the trial doctors to be unsuitable for the study for any other reason

Important: Always verify eligibility with the trial site directly before applying.