Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 80 years, of any gender
• People with bladder cancer who have a tumor biopsy sample taken before starting ADC treatment, which will be used for a laboratory process called organoid culture
• People with bladder cancer that cannot be surgically removed and has either spread to nearby tissues or lymph nodes (locally advanced), or spread to other parts of the body (metastatic), and whose cancer has not responded to platinum-based chemotherapy
• People whose cancer has continued to grow or spread after at least one course of platinum-based chemotherapy, or who have no other satisfactory treatment options available to them
• People who are physically able to tolerate the side effects of the ADC drug enfortumab vedotin
• People with a physical activity and health status score of 0 to 2 on a standard medical scale (meaning they are fully active to capable of some self-care; confirm with trial site)
• People who, in the treating doctor's judgment, are able to follow the trial plan, attend check-ins, report side effects, and participate in follow-up appointments
• People who have chosen to take part voluntarily, understand what the study involves, and have signed a consent form

Who may not be able to join:

• People with locally advanced or metastatic bladder cancer who have never previously received platinum-based chemotherapy
• People with a weakened or impaired immune system, such as those living with AIDS, or those currently using immune-suppressing medications or undergoing radiotherapy
• People who are known to be allergic to the study drug, similar drugs, or their ingredients, or who have a history of multiple drug allergies
• People who take steroid medication long-term, or who have a history of drug abuse or dependence
• People who are planning a pregnancy, are currently pregnant, or are breastfeeding
• People whose blood test results fall outside acceptable ranges, including low counts of certain blood cells, low haemoglobin, poor liver or kidney function, or abnormal blood clotting measures (the trial site can clarify the specific thresholds)
• People who have been diagnosed with, or have a history of, certain blood or bone marrow conditions (myelodysplastic syndromes or acute myeloid leukaemia)
• People with a confirmed history of, or current, serious neurological or psychiatric conditions, such as epilepsy or dementia
• People with serious ongoing health conditions that could put their safety at risk or prevent them from completing the study, such as severe high blood pressure, diabetes, or thyroid disorders
• People with other serious illnesses that require ongoing treatment and are accompanied by significantly abnormal test results
• People with serious illnesses combined with family or social circumstances that could affect their safety or the collection of study data and samples
• People with uncontrolled ongoing conditions, including active infections requiring treatment, heart failure with symptoms, unstable chest pain, or heart rhythm problems
• People the treating doctor considers unsuitable for the study for any other reason

Important: Always verify eligibility with the trial site directly before applying.