Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People who have previously been treated for squamous cell cancer of the voice box (larynx) with radiation therapy
• People who have cancer that has come back, confirmed by a tissue sample (biopsy) — if no stored tissue sample is available, a new biopsy may be taken as part of standard care to confirm the diagnosis
• People who are willing to receive 3 weekly rounds of chemotherapy given under local anaesthetic before surgery
• People whose blood, liver, and kidney function test results fall within the acceptable ranges required by the trial, tested within 6 weeks before treatment starts (confirm specific values with the trial site)
• Women who are not able to become pregnant (due to surgical removal of the uterus and/or ovaries, or who are at least 45 years old with no menstrual period for 12 or more months)
• Women who could potentially become pregnant, provided a pregnancy test at the start of the trial is negative, and a highly effective method of contraception (at least 99% effective) is used from the start of the trial through to at least 14 months after the last dose of trial treatment

Who may not be able to join:

• People who are unable to tolerate being awake and without sedation during procedures on the voice box (a mild sedative tablet may be offered beforehand)
• People who are unable to receive contrast dye (used in certain scans)
• People currently receiving other cancer treatments, such as chemotherapy, radiation, immunotherapy, or other investigational therapies
• People who have received certain cancer treatments too recently before the trial start date — the required waiting periods vary by treatment type (confirm specific timeframes with the trial site)
• People who have not adequately recovered from a major surgery or its complications
• People who have had another cancer within the last 3 years, unless it was a type considered fully cured and low-risk (such as certain skin cancers or early-stage cervical changes — confirm with the trial site)
• People with significant uncontrolled medical conditions affecting the kidneys, liver, blood, digestive system, hormones, lungs, nerves, or mental health
• People with an ongoing serious infection currently requiring antibiotic, antifungal, or antiviral treatment, or who have received a live vaccine within 30 days of the trial dosing date
• People with a known HIV infection or a positive HIV test result (note: HIV testing for this trial is optional)
• People with moderate to severe heart failure (New York Heart Association Class II to IV)
• People with uncontrolled or symptomatic irregular heart rhythm, a stroke within the last 6 months, liver cirrhosis, or an autoimmune condition requiring immune-suppressing medications or long-term steroid use above a certain dose
• People who are currently pregnant or breastfeeding
• People whose overall condition, in the view of the trial doctor, would interfere with safe participation, attending required visits, or the reliability of trial results
• People who do not have the capacity to make informed decisions about their own participation

Important: Always verify eligibility with the trial site directly before applying.