Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a tumour affecting the hypothalamus or the area around the optic chiasm (a specific part of the brain), as classified by the WHO 2021 guidelines.
• People who have developed obesity linked to hypothalamic damage — specifically, those over 5 years of age whose BMI is above the 97th percentile on the WHO 2007 growth charts.
• People aged between 7 and 30 years, either male or female.
• People who are able to carry out a reasonable level of daily activity — measured by the Lansky scale (for those under 18) or the Karnofsky scale (for those aged 18–30), with a score above 40 on either scale (confirm with trial site if unsure what this means for a specific situation).
• People (or their parent or guardian) who are willing and able to sign the informed consent form agreeing to take part in the study.
• Young people aged 7–17 who are also able to provide their own signed agreement to participate, in addition to parent or guardian consent.

Who may not be able to join:

• People who have a known deficiency of primary carnitine (a substance the body needs for energy).
• People who have a deficiency of carnitine palmitoyltransferase 2 (CPT 2), a condition affecting how the body processes fats for energy.
• People who have a deficiency of carnitine acylcarnitine translocase (CACT), another condition affecting fat metabolism.
• People who have a deficiency in the body's ability to break down fats through a process called beta-oxidation.
• People who have a deficiency of medium-chain acyl-CoA dehydrogenase (MCAD), a condition affecting fat processing.
• People who have a deficiency of long-chain acyl-CoA dehydrogenase (LCAD), a similar fat metabolism condition.
• People who have a deficiency of short-chain acyl-CoA dehydrogenase (SCAD), another related fat metabolism condition.
• People who have porphyria (a group of conditions affecting the body's production of a substance called haem).
• People who have a deficiency of pyruvate carboxylase, an enzyme involved in energy production.
• People who have a deficiency of long-chain 3-hydroxyacyl-CoA dehydrogenase, another condition affecting how fats are processed for energy.

Important: Always verify eligibility with the trial site directly before applying.