Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who have been diagnosed by a specialist brain pathologist with glioblastoma (a type of brain tumour) that has come back after previous treatment, and whose tumour has a specific characteristic called IDH-wildtype
• People whose general health and ability to function is above a certain level, as measured by a standard scale used by doctors (confirm with trial site)
• People willing to use an effective form of birth control (such as hormonal, barrier, surgical methods, or abstinence) during the study and for 6 months after the last dose of the study drug — and who will inform their treating doctor immediately if pregnancy occurs or is suspected
• People willing to undergo a brain surgery procedure (craniotomy) for a biopsy and/or removal of tumour tissue, where full removal of the tumour is not expected to be possible
• People willing to formally appoint someone to make decisions on their behalf if needed (a durable power of attorney)
• People who are able to give informed consent themselves, or who have a legally authorised representative who can do so on their behalf

Who may not be able to join:

• People who are pregnant or currently breastfeeding
• People with serious ongoing health conditions that cannot be reasonably managed and that could affect their ability to tolerate the study drug — for example, poorly controlled kidney disease or heart failure (as judged by the investigating doctor)
• People whose personal or social circumstances would make it difficult to follow the study requirements, such as chronic homelessness
• People who have received chemotherapy or certain other cancer-fighting treatments too recently before joining the study (generally within 4–6 weeks, depending on the type of treatment)
• People who have been diagnosed with, or are being actively treated for, another cancer within the past year
• People who are unable to have an MRI scan of the brain
• People who have an active autoimmune disease (where the immune system attacks the body) that has required whole-body treatment within the past 2 years
• People with certain heart conditions, including: two or more heart attacks; two or more procedures to open blocked heart arteries; certain abnormal heart enzyme levels on blood tests; or a heart pumping function below 45% on an ultrasound of the heart
• People with persistently very low potassium levels in the blood
• People with a known history of HIV, or who test positive for HIV at screening
• People with an active Hepatitis B or Hepatitis C infection at the time of screening
• People with an active infection that is currently being treated with antibiotics, antiviral, or antifungal medicines within 7 days before starting the study drug
• People who have previously received certain types of immune cell therapies (autologous or allogeneic T cells)
• People who have received a solid organ or tissue transplant

Important: Always verify eligibility with the trial site directly before applying.