Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You fully understand the study, agree to take part voluntarily, and are willing to sign a consent form.
• You are a woman between 18 and 75 years old (inclusive).
• Your doctor estimates you are expected to live for at least 3 months or more.
• Your cancer has been confirmed by a tissue sample (biopsy) to be squamous cell carcinoma of the cervix, vagina, or vulva.
• You have already received at least one standard treatment that included both a platinum-based chemotherapy and an immunotherapy drug, and you have had no more than 4 previous lines of treatment in total.
• You are generally well enough to carry out light daily activities, with little or no limitation (this is measured on a standard scale called ECOG — confirm with trial site if unsure of your score).
• You have at least one area of cancer that can be measured on a scan, according to standard measurement guidelines.
• Your blood counts are within acceptable ranges, meaning your bone marrow is producing enough blood cells (confirm specific values with trial site).
• Your liver and kidney function blood test results are within acceptable ranges (confirm specific values with trial site).
• You are not pregnant or breastfeeding, and if you could become pregnant, you have had a negative pregnancy blood test within 28 days before joining and agree to use effective contraception from signing the consent form until 6 months after your last dose of the study drug.
• You agree to provide blood and tissue samples for the study.

Who may not be able to join:

• You have a known allergy or serious reaction to any of the study drugs or their ingredients.
• You have taken certain medications that strongly interact with the study drug — including some epilepsy medicines (such as phenytoin, phenobarbital, or carbamazepine), rifampicin, rifabutin, or St. John's Wort in the past 2 weeks; or certain antibiotics, antifungals, or HIV medicines, or consumed grapefruit juice in the past week (confirm full list with trial site).
• Your cancer has spread to the brain, spinal cord, or the lining around the brain or spinal cord.
• You have an uncontrolled ongoing illness (such as a serious infection, uncontrolled high blood pressure, or uncontrolled diabetes), or a mental health or personal situation that would make it difficult to follow the study requirements.
• You have a confirmed bowel blockage on a scan, or a history of inflammatory bowel disease, Crohn's disease, ulcerative colitis, or major bowel surgery that caused long-term diarrhoea.
• You have an active hepatitis B or hepatitis C infection with detectable virus levels in your blood (confirm specific levels with trial site).
• You have HIV infection (confirmed by a positive HIV antibody test).
• You have had major surgery or a serious injury within the 30 days before starting the study, or have major surgery planned within 30 days after starting.
• You are pregnant, breastfeeding, or could become pregnant and are unwilling to use effective contraception.
• Your doctor considers there to be any other reason you would not be suitable for this study.

Important: Always verify eligibility with the trial site directly before applying.