Phase 1 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with thyroid cancer that has been confirmed by a laboratory test, and if it is a certain type (differentiated thyroid cancer), a specialist has determined it no longer responds to radioactive iodine treatment.
• Your cancer has been shown to be growing or spreading based on recent scans, using a standard measurement system called RECIST 1.1.
• You have already had surgery to remove tumors in the neck area that could be removed, but the cancer has now spread to areas that cannot be surgically removed.
• You previously received a targeted drug treatment that was stopped because of side effects, because it wasn't working, or because you chose to stop it.
• You have at least one tumor that can be measured on a CT or MRI scan (meeting specific size requirements).
• A special type of scan (68Ga-CTR-FAPI PET/CT) shows that more than half of your tumors have a high uptake of a specific tracer (confirm with trial site for technical details).
• Your doctor estimates you are expected to live longer than 6 months.
• You are able to carry out basic daily activities, with your overall health and functioning rated at a certain level or better (confirm with trial site).
• Any side effects from previous cancer treatments have mostly cleared up, except for things like hair loss or certain long-term effects considered permanent.
• If you are able to have children, you agree to use effective birth control during treatment and for several months after the last dose (4 months for males, 7 months for females).
• You are willing to take part and have signed a consent form.

Who may not be able to join:

• Some of your tumors show up on a CT or MRI scan but do not show up on the special tracer scan (68Ga-CTR-FAPI PET/CT).
• You have previously received a type of radiation treatment delivered through the bloodstream, except for radioactive iodine (131I).
• You have received any systemic cancer treatment (such as chemotherapy, targeted therapy, immunotherapy, or certain traditional medicines) within the 4 weeks before starting the trial.
• You have taken part in another clinical trial for a drug or medical device within the 4 weeks before starting the trial.
• Your major organs (such as liver, kidneys, or heart) are not functioning well enough (confirm with trial site for specific thresholds).
• You have serious or poorly controlled other health conditions.
• You have fluid buildup around your lungs or in your abdomen that needs treatment or is considered uncontrolled.
• You have had an active infection within the 4 weeks before starting the trial.
• You are pregnant, breastfeeding, or planning to become pregnant.
• You have a known allergy to contrast dyes used in scans.
• You have had brain or spinal cord metastases that have caused symptoms.
• You currently have or are being treated for another type of cancer.
• You have had surgery requiring general anesthesia within the 8 weeks before starting the trial.
• You have had a heart attack or stroke within the 8 weeks before starting the trial.
• You have severe claustrophobia (fear of enclosed spaces, which could affect your ability to have scans).
• The trial doctor feels there is any other reason you should not take part, such as difficulty following the treatment plan or attending follow-up visits.

Important: Always verify eligibility with the trial site directly before applying.