Phase 1 Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to understand the trial procedures and possible side effects, and are willing to sign a written consent form.
• People aged between 18 and 75 years old at the time of signing the consent form.
• People with a body mass index (BMI) between 19.0 and 32.0, and who weigh at least 50 kg (for men) or at least 45 kg (for women).
• People who have been diagnosed with stable, long-term kidney disease for at least 3 months.
• People whose kidney function — measured by a specific kidney filtration test (eGFR) — falls into one of four categories: normal kidney function, mild reduction in kidney function, moderate reduction in kidney function, or severe reduction in kidney function.
• People whose kidney function has remained stable across two separate measurements taken during the screening period.

Who may not be able to join:

• People with a history of pancreas inflammation (pancreatitis) or pancreatic injury.
• People with a personal or family history of a specific type of thyroid cancer (medullary thyroid carcinoma) or a related hormonal condition (type 2 multiple endocrine neoplasia).
• People with a history of depression, anxiety disorder, or any severe psychiatric condition.
• People who have had any type of cancer in the 5 years before screening, whether treated or not (with the exception of a certain type of skin cancer called basal cell carcinoma, or cervical carcinoma in situ that has been cured).
• People in the kidney disease group whose kidney problems are caused by blockages in the urinary tract, kidney tumours, narrowed kidney arteries, certain medications, severe infections, low blood volume, or heart failure — if the trial doctor considers this makes them unsuitable.
• People in the kidney disease group whose blood pressure during screening is higher than 160/100 mmHg.
• People in the kidney disease group who have taken certain medications that affect how the kidneys process a waste product called creatinine, or medications that are harmful to the kidneys, within 14 days before screening (or longer, depending on the medication).
• People in the normal kidney function group who have had significant health conditions affecting the heart, lungs, digestive system, hormones, blood, or mental health within the past year, if the trial doctor considers this makes them unsuitable.
• People in the normal kidney function group whose blood pressure falls outside the range of 90–140 mmHg (systolic) or 50–90 mmHg (diastolic).
• People in the normal kidney function group who have taken any medications — including prescription drugs, over-the-counter medicines, herbal medicines, or supplements such as vitamins and minerals — within 14 days before screening (or longer, depending on the medication).

Important: Always verify eligibility with the trial site directly before applying.