Phase 1 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with unresectable (cannot be surgically removed) Stage IIIB, IIIC, or Stage IV squamous cell lung cancer, confirmed by a tissue or cell sample test
• People whose cancer tests positive for a protein called GPC3, as measured by a specific lab test done at a central laboratory
• People whose cancer has continued to grow or who could not tolerate up to three previous treatment regimens for advanced or metastatic squamous cell lung cancer
• People who have at least one tumour that can be measured on scans
• People whose heart pumping function (measured by an echocardiogram) is at 50% or above and is reported as normal
• People who have adequate lung function
• People whose blood test results meet the study's required levels
• Female participants of childbearing potential who test negative for pregnancy, and all non-sterilised participants (male and female) who agree to use effective contraception for at least 12 months and until the CAR-T cells are no longer detectable in the body after the infusion

Who may not be able to join:

• People whose cancer has a specific genetic mutation for which a targeted standard treatment is already recommended under local treatment guidelines
• People with known serious allergies or intolerances to the CAR-T cell product or any of its ingredients, including a substance called DMSO
• People who have medical reasons preventing them from receiving the preparatory chemotherapy drugs (fludarabine and/or cyclophosphamide) used before the CAR-T treatment
• People who have had their spleen removed or have had an organ transplant
• People who have previously received any CAR-T cell therapy, or any treatment specifically targeting the GPC3 protein
• People with uncontrolled or ongoing serious lung disease
• People with a clinically significant build-up of fluid in the abdomen
• People with uncontrolled fluid build-up around the lungs or heart that requires repeated draining procedures
• People with cancer that has spread to the spinal cord, the lining of the brain or spinal cord, or the brain
• People who have received radiation therapy, certain local treatments, vaccines, blood transfusions, or systemic treatments within specific time periods before the cell collection procedure, as defined by the study protocol
• People with a history of, or currently active, certain medical conditions or diseases as defined in the study protocol (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.