Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People with a good general level of physical functioning, able to carry out normal daily activities with little or no limitation (as measured by a standard medical scale called ECOG 0–1).
• People who have been confirmed by laboratory testing to have Stage III or Stage IVA squamous cell carcinoma (a specific type of cancer) in the head or neck area, including the mouth, throat, voice box, or surrounding structures.
• People whose cancer falls into one of three groups: tumors that a surgical team considers removable upfront; tumors that may be removable but where surgery carries significant risks such as major disfigurement or loss of function (requiring specialist team discussion); or tumors that are too advanced for surgery due to involvement of critical nearby structures (confirm with trial site for exact grouping).
• People whose blood test shows that a specific type of immune cell, called an exhausted T cell (identified by the markers PD-1, TIM-3, and CD8), makes up more than 10% of a certain group of immune cells in the blood.
• People whose blood, kidney, and liver function results, taken within 14 days before joining, meet the required levels set by the trial (confirm specific values with trial site).
• People who are able to understand the trial information, are willing to sign a consent form, and are able to attend all required appointments and follow-up visits.

Who may not be able to join:

• People who have previously received certain types of immunotherapy drugs (such as anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 treatments) or a type of medication called JAK inhibitors, or who have had a severe allergic reaction to similar medications.
• People who have an active autoimmune disease (where the immune system attacks the body) or who are currently taking steroid medications or other drugs that suppress the immune system.
• People who have another active cancer, or an active infection such as tuberculosis, hepatitis, HIV, or related conditions that are not controlled.
• People with serious heart or lung problems, bleeding or clotting disorders, a history of blood clot disease, or who are currently taking blood-thinning or clot-dissolving medications.
• People who are pregnant or breastfeeding, or who are unwilling to use effective contraception throughout the trial period.

Important: Always verify eligibility with the trial site directly before applying.