Phase 1 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given written consent to participate
• People aged 18 or older
• People who have head and neck squamous cell cancer (a type of mouth, throat, or related cancer) confirmed by biopsy, shown on imaging as a returning cancer, or being surgically removed as a suspected case
• People whose blood, liver, and organ function are healthy enough to safely undergo surgery and anesthesia, as confirmed by tests done within 30 days of the study infusion
• People who are well enough to carry out daily activities, as measured by standard medical performance scales (confirm with trial site)

Who may not be able to join:

• People who are not already planning to have standard surgical removal of their cancer as part of their care
• People who have, or have had, an autoimmune disease or immune system deficiency — including conditions such as HIV, lupus, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, inflammatory bowel disease, Sjögren syndrome, Guillain-Barré syndrome, and several others — though some exceptions may apply, including:
  • People with autoimmune-related underactive thyroid who are already on thyroid hormone replacement
  • People with well-managed Type 1 diabetes who use insulin
  • People with certain skin conditions only (such as eczema, psoriasis, or vitiligo), provided the rash covers less than 10% of the body, is well controlled with only mild topical creams, and has not required stronger treatments in the past 12 months
• People with a history of hepatitis C that has not been fully treated with the aim of curing it
• People with a history of certain lung conditions, including idiopathic pulmonary fibrosis, a type of lung inflammation called organizing pneumonia, medication-caused lung inflammation, or unexplained lung inflammation — or people who show signs of active lung inflammation on a chest scan while on active treatment
• People who have had a significant heart or blood vessel problem — such as a heart attack, stroke, or a moderate-to-severe heart condition — within the 3 months before starting the study, or who have an unstable heart rhythm or unstable chest pain
• People with a severe unresolved infection within 4 weeks before starting the study
• People who have previously received a bone marrow (stem cell) or organ transplant from another person
• People who have had a severe allergic reaction to certain types of laboratory-made antibody treatments in the past
• People who are currently taking ongoing, high-dose immune-suppressing medications — such as steroids above a low daily threshold, cyclophosphamide, methotrexate, or similar drugs — though several exceptions may apply, including people who use inhaled or topical steroids, short courses of steroids for specific reasons, or low-dose steroids for hormone deficiency conditions (confirm with trial site for specific details)
• People who are pregnant, breastfeeding, or planning to become pregnant during the study or within 2 months after the last dose of the study drug
• People whose heart's electrical activity (measured by a specific interval on a heart tracing) is above a certain level at the start of the study (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.