Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People with a bladder cancer diagnosis confirmed by laboratory testing, specifically a type called urothelial carcinoma that has not grown into the bladder muscle, and classified as "very high risk" based on 2025 European urology guidelines
• People whose cancer has been assessed by a specialist team as not fully removable through standard bladder surgery
• People who are either not medically suitable for full bladder removal surgery, or who have decided against it after discussing options with their treating team
• People who have at least one area of bladder disease that can be monitored and measured through camera examinations, tissue samples, or urine tests
• People with a general health and activity level rated as reasonably functional (confirm with trial site for specific rating details)
• People whose blood, liver, and kidney test results meet certain minimum levels of healthy function (confirm with trial site for specific values)
• People who are able to provide urine samples throughout the trial for testing purposes

Who may not be able to join:

• People whose bladder cancer has grown into the bladder muscle, spread to nearby tissues beyond the bladder lining, or spread to other parts of the body
• People whose bladder cancer is predominantly or entirely a non-urothelial type, where the investigator considers this unsuitable for the trial
• People who have previously received immunotherapy treatment
• People with an active autoimmune disease, or a history of autoimmune disease that required ongoing immune-suppressing treatment, considered incompatible with the type of treatment used in this trial
• People currently taking immune-suppressing medications above the levels allowed by the trial
• People with an active, uncontrolled infection — including an uncontrolled urinary tract infection — that could interfere with treatment or results
• People with any medical condition that the investigator considers would make it unsafe to receive the study treatment or undergo the required procedures
• People with another active cancer at the same time
• People who are pregnant or breastfeeding
• People who would be unable to follow the trial procedures or attend required follow-up visits

Important: Always verify eligibility with the trial site directly before applying.