Spinal Muscular Atrophy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with at least one of the following conditions: ALS (amyotrophic lateral sclerosis), primary lateral sclerosis, progressive muscle atrophy, spinal muscular atrophy, post-polio syndrome, inclusion body myositis, Pompe disease, facioscapulohumeral muscular dystrophy, Charcot-Marie-Tooth disease, chronic inflammatory demyelinating polyneuropathy, hereditary spastic paraplegia, myasthenia gravis, Lambert-Eaton myasthenic syndrome, postural orthostatic tachycardia syndrome, mitochondrial myopathy, nemaline myopathy, centronuclear myopathy, lumbar radiculopathy, or non-specific low back pain
• You are able to stand continuously for about 15 minutes, with or without a walking aid or other assistive device (for example, long enough to take a shower or prepare a meal)
• You have at least some ability to move your major muscle groups against gravity, as measured by a standard muscle strength test (confirm with trial site)
• Your doctor has cleared you to take part in an exercise program
• You are able to understand and sign a consent form agreeing to take part in the study
• You are able to meet the study's requirements, such as attending all scheduled visits, keeping your current level of physical activity the same throughout the study, and not planning to move away during the study

Who may not be able to join:

• You have been diagnosed with Becker muscular dystrophy, Duchenne muscular dystrophy, limb-girdle muscular dystrophy, myotonic dystrophy type 1 or 2, Friedreich's ataxia, or any other neuromuscular condition known or suspected to affect the heart or the structural integrity of muscle fibers
• You are currently taking part in another research study that involves a treatment or intervention
• You are unable to stand continuously for 15 minutes, even with the help of an assistive device
• You have a pacemaker, metal implants, or other implanted medical devices that could affect your safety during a specific type of electrical muscle stimulation used in this study (confirm with trial site)
• You have a cochlear implant, a brain stimulator (such as a deep brain stimulator or cortical stimulator), a shunt in your brain, a recent opening in your skull, a seizure in the past 12 months while on anti-seizure medication, or a previous serious reaction to a brain scanning technique called TMS (confirm with trial site)
• You have an unstable ongoing or long-term illness, such as kidney failure, uncontrolled high blood pressure, an irregular heartbeat, a rheumatic disease, or cancer
• You are known to be pregnant at the time of screening (verbal checks will continue throughout the study)
• You have a terminal illness and are currently receiving hospice or end-of-life care
• You have used any medications known to affect muscle size or strength in the past 6 months, such as anabolic steroids, growth hormone, or certain hormone therapies (confirm with trial site for a full list)
• You have another neurological condition that affects movement or sensation, such as Parkinson's disease, multiple sclerosis, history of stroke, traumatic brain injury, spinal cord injury, or similar conditions
• You have had a significant bone or joint problem, or surgery in the past year that could affect the results of the exercise portions of the study, such as knee or hip replacement, rotator cuff repair, or spinal fusion
• You have any other health condition, sign, or symptom that a study investigator determines could interfere with the study or its results

Important: Always verify eligibility with the trial site directly before applying.