Phase 2 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old and able to give your consent to participate
• Imaging tests (such as an MRI) show that you have a significant amount of fat in your liver, consistent with a condition called MASLD or NAFLD
• Tests suggest your liver scarring (fibrosis) is at an early stage — meaning you do not have advanced scarring (cirrhosis) or signs of serious liver complications
• Your body weight has been fairly stable (within about 5%) for at least the last 3 months
• If you take medications for diabetes, cholesterol, blood pressure, or weight loss, your doses have been unchanged for at least 3 months and are expected to stay the same throughout the study
• You are willing and able to give yourself a daily injection under the skin, or have a caregiver who can do this for you
• If you could become pregnant, you agree to use reliable birth control during the study and for 30 days after your last dose, and you have a negative pregnancy test at the start

Who may not be able to join:

• You drink alcohol heavily on a regular basis (roughly more than one to two drinks per day, depending on your sex), enough to be causing liver damage
• You have another ongoing liver condition, such as hepatitis B, hepatitis C, autoimmune hepatitis, or certain inherited liver diseases
• You have been diagnosed with advanced liver scarring (cirrhosis) or serious liver failure
• Your diabetes is poorly controlled, or you have an active, untreated eye condition related to diabetes (confirm with trial site)
• You have used growth hormone or similar medications in the past 12 months
• You regularly take steroid medications or certain other drugs known to cause or worsen liver damage (such as amiodarone, tamoxifen, or methotrexate)
• You currently have cancer or are considered at high risk of cancer returning
• You have a medical implant or other reason that makes having an MRI scan unsafe
• You are currently pregnant or breastfeeding
• You have a known allergy to the study drug (tesamorelin) or any of its ingredients, such as mannitol
• You have had weight-loss (bariatric) surgery in the past 12 months, or you are planning to have it during the study

Important: Always verify eligibility with the trial site directly before applying.