Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People who have been diagnosed through laboratory testing with a type of head and neck cancer called squamous cell carcinoma (not including cancers of the nasopharynx, salivary glands, or thyroid), where a surgeon has assessed the tumour as removable or potentially removable
• People whose general health and ability to carry out daily activities falls within an acceptable range, as measured by a standard medical scoring system (scores 0, 1, or 2 on the ECOG scale)
• People whose blood counts, liver function, kidney function, and blood clotting results meet specific minimum levels set by the trial (confirm exact values with the trial site)
• People who are willing to give written consent to participate and are able to attend scheduled visits and follow the trial procedures

Who may not be able to join:

• People who have had another type of cancer in the past 5 years, unless it was fully treated and has not returned (certain low-risk skin cancers and early-stage cancers may be exceptions — confirm with trial site)
• People who have an active autoimmune disease (where the immune system attacks the body) or a history of one, with the exception of type 1 diabetes that is stable on insulin
• People who have a history of severe allergic reactions requiring hospitalisation, or who are known to be allergic to the types of medicines being used in this trial
• People who have previously received certain types of immune checkpoint therapy (anti-PD-1, PD-L1, or anti-CTLA-4 medicines), a TROP2 antibody-drug treatment, or an anti-cancer vaccine
• People who have received a live vaccine within the 4 weeks before the trial starts, or who plan to receive one during the trial; also people who have had major surgery or a serious injury within the 4 weeks before starting
• People who have been taking medium-to-high dose steroid tablets or other medicines that suppress the immune system within the 14 days before starting (inhaled or skin-applied steroids and hormone replacement for adrenal conditions are generally permitted — confirm with trial site)
• People with serious heart conditions, including certain types of heart failure, blocked heart arteries, significant heart rhythm problems, low heart pumping function, or an abnormal heart electrical reading
• People with a known history of a lung scarring condition called interstitial lung disease, or active or uncontrolled tuberculosis
• People with an overactive thyroid or other thyroid gland disease (people with an underactive thyroid that is stable on medication may still be considered — confirm with trial site)
• People with an active infection, an unexplained fever in the 48 hours before starting, or who have been on antibiotic tablets or injections in the week before signing consent
• People with active hepatitis B or C at certain levels of viral activity, a positive HIV test, or a history of AIDS
• People with a confirmed diagnosis of a neurological or psychiatric condition such as epilepsy or dementia
• People with a history of drug or alcohol misuse
• People who are pregnant or breastfeeding; also people (or their partners) who are planning a pregnancy or who are not willing to use effective contraception during the trial and for 3 months after it ends
• People who have taken part in another clinical drug trial within the 4 weeks before starting, or who are currently enrolled in another interventional trial
• People whom the trial doctors consider unsuitable for any other reason

Important: Always verify eligibility with the trial site directly before applying.