Multiple Sclerosis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are aged 60 or older
• People who have multiple sclerosis but whose other long-term health conditions (if any) are well managed
• People who have not been following a structured exercise program (meaning two or more exercise sessions per week) in the past six months
• People who are mentally able to understand and agree to participate in the study
• People whose multiple sclerosis disability level falls within a specific range on a standard scale used by neurologists (called the EDSS score, between 2 and 5.5) — this would be checked during a screening appointment

Who may not be able to join:

• People who have a muscle, nerve, or bone and joint condition (other than multiple sclerosis) that would make it difficult to do exercise or testing activities
• People who have heart or lung conditions, or reduced breathing capacity
• People who have metabolic conditions such as type 2 diabetes, or blood test results showing signs of liver disease
• People who are taking metformin (a common diabetes medication) at any dose
• People who have another disease or condition that could affect how their body responds to exercise, such as chronic kidney disease, Alzheimer's disease, active cancer, cancer in remission within the past two years, or a history of stroke or related conditions
• People who have had chemotherapy within the past five years
• People who take blood-thinning medications (such as Coumadin or Pradaxa) that cannot be changed or stopped — clinical staff would determine this
• People who take medications that lower blood sugar or affect metabolism, such as metformin or GLP-1 drugs (a type of weight and blood sugar medication)
• People who take high-dose statin medications (40 mg or more)
• People who have a visual impairment that cannot be corrected with glasses or lenses
• People who score below 29 on a specific thinking and processing speed test called the Symbol Digit Test
• People who have received Botox injections for muscle stiffness within the three months before the study begins
• People who would need to make changes to their Baclofen medication (a muscle relaxant) during the study period
• People who are unable to commit to approximately four months to complete the full study
• People who have an allergy to lidocaine (a local anaesthetic)
• People who currently use tobacco products
• People whose alcohol consumption is above recommended limits (more than three drinks per day or seven per week for women; more than four drinks per day for men — confirm exact weekly limit for men with trial site)
• People with a body mass index (BMI) greater than 35.0

Important: Always verify eligibility with the trial site directly before applying.