Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given written consent to take part before enrolling
• People aged between 18 and 75 years
• People who have been diagnosed with a specific type of lung cancer called non-small cell lung adenocarcinoma, confirmed by laboratory tissue testing, and whose tumour has been confirmed to carry certain EGFR gene changes (specifically a deletion in exon 19 or a mutation called L858R in exon 21)
• People who have cancer that has spread to the brain, confirmed by a contrast-enhanced CT or MRI scan, with between 1 and 10 brain tumour spots that may need targeted radiation, at least one brain spot measuring 10mm or more, and at least one measurable tumour spot outside the brain confirmed by appropriate imaging
• People who are experiencing symptoms caused by their brain metastases
• People whose general physical functioning is rated 0, 1, or 2 on a standard medical scale (ECOG), meaning they are able to carry out daily activities with no more than moderate limitation (confirm with trial site)
• People whose doctors estimate they are likely to live at least 12 weeks or more
• People who have not previously received any anti-cancer treatment for their lung cancer
• People whose blood, liver, kidney, and heart function meet specific laboratory thresholds set by the trial (confirm with trial site for exact values)
• People who are not surgically sterilised and women who could become pregnant must be using an approved method of contraception during treatment and for 3 months after treatment ends, and women who could become pregnant must have a negative pregnancy test within 7 days before enrolling and must not be breastfeeding
• People who are willing to take part voluntarily, follow the study requirements, and attend safety and survival follow-up appointments

Who may not be able to join:

• People who have uncontrolled fluid build-up in body cavities (such as around the lungs or in the abdomen) that cannot be managed by draining or other means
• People who have conditions that would prevent them from taking oral medications properly, such as difficulty swallowing, previous removal of part of the digestive tract, ongoing severe diarrhoea, or bowel obstruction
• People who are known to be pregnant, planning to become pregnant, or women who could become pregnant and are not willing to use effective contraception throughout the study
• People who have serious other illnesses or who the trial doctor considers unsuitable for enrolment for any reason
• People whose cancer has spread to the lining surrounding the brain and spinal cord (meningeal metastasis)
• People who have taken part in another drug clinical trial within the 4 weeks before enrolling
• People who are currently receiving any other anti-cancer treatment
• People with a known history of misusing psychiatric medications, excessive alcohol use, or drug addiction
• People with existing conditions that may interact with the study drugs, such as clinically significant heart rhythm abnormalities or active inflammatory lung disease
• People whom the trial doctor considers unsuitable for any other reason that could affect their safety or ability to meet the study requirements

Important: Always verify eligibility with the trial site directly before applying.