Phase 3 Osteoarthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who were male or female at birth, aged 18 or older at the time of signing the consent form
• People who have been clinically diagnosed with knee osteoarthritis and have confirmed changes visible on X-ray in the knee being studied (rated at a certain level of severity by a central reviewer)
• People whose knee osteoarthritis pain in the target knee first appeared more than 90 days before the screening visit, and who had pain on more than 15 days out of the past 30 days
• People who are willing to stop taking most pain relief medications for 72 hours before certain study visits (a limited amount of paracetamol is allowed up until 24 hours before those visits)

Who may not be able to join:

• People whose blood sugar marker (HbA1c) is measured at 6.5% or above in the screening blood test
• People who have a history of type 1 or type 2 diabetes, either as reported by themselves or recorded in their medical history
• People who have previously been treated with a class of medications known as GLP-1 receptor agonists, dual GLP-1/GIP receptor agonists, or amylin analogues (confirm with trial site if unsure whether a current or past medication falls into these categories)
• People who have an artificial joint or joint replacement in the knee being studied
• People who have had a knee scope procedure (arthroscopy) or an injection into the target knee within the 90 days before screening
• People who have any other joint condition affecting the target knee, including gout or pseudogout

Important: Always verify eligibility with the trial site directly before applying.