Phase 1 Obesity Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Female participants must have a negative pregnancy test at the screening visit and at the time of admission to the clinic.
- Female participants who cannot become pregnant must be confirmed as postmenopausal, or have records showing they have had a hysterectomy, removal of both ovaries, or removal of both fallopian tubes.
- Body mass index (a measure of weight relative to height) must fall within a certain range — between 25 and 39.9 for the general (Global) groups, or between 23 and 39.9 for the Japanese and Chinese groups — and participants must weigh at least 50 kg.
- For the Japanese groups (Parts A2 and B2), participants must be of Japanese heritage, with both parents and all four grandparents being Japanese, including second- and third-generation individuals of Japanese descent whose family members live outside Japan.
- For the Chinese group (Part A3), participants must be of Chinese heritage, with both parents and all four grandparents being ethnically Chinese, including second- and third-generation individuals whose family members live outside China.
Who may not be able to join:
- People with a history of any significant disease or medical condition.
- People with a history or current presence of stomach, bowel, liver, or kidney problems, or any condition that could affect how the body processes medications.
- People who have had a significant illness, surgery, or injury within the four weeks before the first dose of the study treatment.
- People with significant abnormalities in blood tests, urine tests, or vital signs (such as blood pressure or heart rate).
- People with a history of severe allergic reactions, or an ongoing significant allergy, to medications in the same drug family as AZD1043.
- People who have taken prescription, over-the-counter, or experimental weight loss medications within the three months before the screening visit.
- People with a history of psychosis, bipolar disorder, or major depressive disorder within the past two years who are currently not in a stable condition.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 1-877-240-9479
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Number of participants with adverse events (AEs), serious adverse events (SAEs), AE leading to discontinuation (DAEs), and AEs of special interest (AESIs)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.