Brain Cancer Trial, Recruiting NCT07512154 Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Condition: Brain Cancer
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Brain Cancer Trial, Recruiting

NCT07512154
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with glioblastoma or grade 4 astrocytoma, confirmed by a tissue test (biopsy or surgery)
  • People aged 18 or older
  • People who are well enough to carry out some daily activities (measured by a standard health scale called the Karnofsky Performance Scale, with a score of at least 60)
  • People whose blood counts and organ function (including white blood cells, platelets, liver, and kidneys) fall within acceptable ranges as measured by blood tests
  • People who are able to use reliable contraception during the study, as radiation therapy may be harmful to an unborn child — this applies to both male and female participants who are capable of having children
  • People who are able to understand the study and are willing to sign a consent form agreeing to take part

Who may not be able to join:

  • People who are unable to have MRI scans
  • People who are currently taking part in another experimental cancer treatment trial at the time of joining
  • People who have previously had a course of radiation therapy to the brain that overlaps with the area that would be treated in this trial
  • People with serious uncontrolled health conditions, such as an active infection, heart failure, unstable chest pain, irregular heart rhythm, or mental health or personal circumstances that would make it difficult to follow the study requirements
  • People who are pregnant or breastfeeding
  • Female participants of childbearing potential who are unable or unwilling to use an accepted form of contraception throughout the entire study period and for up to 12 weeks after the study ends
  • Male participants who are unwilling to use effective contraception for the same period

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 19 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Kristin Redmond, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Phone: 410-614-1642

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
29 April 2026
Est. completion
1 May 2031

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in APTw signal (Efficacy of APT-RT)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov