Phase 1 study
Not yet recruiting Phase 1
This trial at a glance
Past estimated completion. The registry still lists this trial as open, and the date it gave for finishing has been and gone. Confirm with the official record before you act on it.
Where this trial is running
| Site | City | State or country | Status at this site |
|---|---|---|---|
| Argo Investigative Site | Melbourne | VIC | Status not stated |
voxsanity.com.au · trial sites from public registries · registry record synced 11 October 2026 · not medical advice
Who can join
The official eligibility criteria
Registry text, reproduced exactly. These are the words the trial's sponsor published on ClinicalTrials.gov. They have not been edited, shortened or rewritten, and they are written for researchers rather than for patients.
Inclusion Criteria:
* Must have given written informed consent and be able to comply with all study requirements
* Males or females aged 18 to 60 years old, inclusive, at the time of informed consent.
* Body mass index (BMI) ≥18 and ≤32 kg/m2 and body weight ≥50 kg Female participants must be non-pregnant
* Male participants with female partners of child-bearing potential must agree to use acceptable methods of contraception from screening until 48 weeks following administration of the study drug
Exclusion Criteria:
* Any clinically significant chronic medical condition or clinically significant abnormality in physical examination that
* Any skin condition and/or tattoo that may interfere with the evaluation of safety at the injection site
* Hospitalization for any reason within 60 days prior to screening.
* Presence of carcinoma and history of carcinoma
* Any clinically significant acute condition
* Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg after at least 5 minutes resting
* Clinical laboratory findings outside of range are deemed clinically significant by the investigator at screening
* Participants with ANY in clinical laboratory tests at screening or Day-1.
* History of bleeding diathesis or clinically significant hemorrhagic disorders Positive for hepatitis B surface antigen
* Single 12-lead ECG with clinically significant abnormalities at screening or Day -1
* Use of an investigation agent or device within 30 days or 5 half-lives (whichever is longer) before the study drug administration.
* Used prescription drugs, excluding hormonal contraceptives
* Used over-the-counter (OTC) medications
* Have received treatment with small interfering RNA (siRNA) within the last 12 months
* History of allergic reactions to synthetic siRNA or GalNAc and/or any other clinically significant allergic reactions.
* Use of more than 10 tobacco/nicotine containing products or equivalent per day within 30 days prior to screening and not willing to abstain for 48 hours prior to admission to the unit
* History or clinical evidence of alcohol substance abuse, within the 12 months before screening
* History or clinical evidence of drug abuse, within the 12 months before screening
* Positive test for alcohol or drugs of abuse at screening or Day -1
* Have received vaccination with a live vaccine
* Donated or lost \>200 mL of blood or plasma within 30 days prior to screening
* Any conditions which, in the opinion of the Investigator
Dates on the record
Results, publications and the official record
- No results are posted on the official record yet.
- No publications are listed on the official record yet.
- Official record and contacts on ClinicalTrials.gov – contact details for each site are kept there, and are not copied onto this page.
Sources and dates
- ClinicalTrials.gov – the record this page reformats
- ClinicalTrials.gov processing date: 21 April 2026.
- This page last checked by Voxsanity: 11 October 2026.
Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.
Not medical advice.
Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.
Letter for your doctor
A one-page summary of this trial to print or email to your GP. It carries the registry's own record of the trial and its eligibility criteria, and nothing Voxsanity has written about whether it suits you.