Phase 3 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older at the time of giving consent
• People whose general health and ability to carry out daily activities falls within a certain range, as measured by a standard medical scoring tool called the ECOG scale (scores 0–2, meaning fully active to capable of self-care) (confirm with trial site)
• People who have been diagnosed with a specific type of skin melanoma — either Superficial Spreading Melanoma or Nodular Melanoma — confirmed by laboratory analysis of tissue, at a stage between pT1b and pT4b according to a standard medical staging system
• People whose melanoma was fully removed by a diagnostic surgical excision with at least 1 mm of clear (tumour-free) tissue around the entire removal, including any melanoma that had not yet grown deep into the skin
• People who are willing and able to follow the treatment plan and attend follow-up appointments, and who have given their informed consent to participate
• People whose general health (not counting the current melanoma) means a doctor estimates they are likely to live at least 5 more years
• People who have had a previous cancer may still be considered, provided that: all previous cancers were treated with the intention of curing them, their expected lifespan is at least 5 years, and their treating doctor considers them to be at low risk of that previous cancer returning

Who may not be able to join:

• People whose melanoma started somewhere other than the skin, such as in the eye or in mucous membranes (for example, mouth or nasal passages)
• People with acral melanoma (a type found on the palms, soles, or under nails)
• People with a type of melanoma called Lentigo Maligna Melanoma
• People with desmoplastic melanoma
• People with neurotropic melanoma (a type that tends to spread along nerves)
• People with Spitz melanoma or malignant Spitz tumour
• People whose melanoma has already spread to nearby skin or lymph nodes, or where visible spread to other parts of the body has been detected
• People where the diagnosis of melanoma is uncertain — for example, lesions described as being of unknown malignant potential
• People with a melanoma subtype other than Superficial Spreading Melanoma or Nodular Melanoma
• People whose melanoma was removed using a shave excision, a scraping technique, or a core biopsy (rather than a full surgical excision)
• People who have already had reconstructive surgery using a local skin flap at the site where the melanoma was removed
• People who have a history of a previous or second separate invasive melanoma
• People with more than one melanoma
• People who have previously had lymph node removal surgery in the area likely to drain from the melanoma site, unless that surgery was a sentinel lymph node biopsy only
• People who have had any other cancer (solid tumour or blood cancer) in the past 5 years where life expectancy is estimated at less than 5 years
• People who have had an organ transplant

Important: Always verify eligibility with the trial site directly before applying.