Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 to 80 years old
• People who have been diagnosed with an acquired brain injury, a spinal cord injury (at a specific level and severity range, confirm with trial site), or multiple sclerosis
• People who are currently receiving physiotherapy treatment, either as a hospital inpatient or an outpatient, at the centre running the trial
• People who are able to give their own informed consent to participate

Who may not be able to join:

• People with significant bone thinning (osteoporosis) that may raise the risk of broken bones
• People with unhealed fractures in the pelvis or legs, or who have had a fragility fracture in the lower limbs within the past 2 years
• People with an unstable spine, or who use a spinal brace unless medically approved
• People whose spinal cord injury neurological assessment has worsened notably in the past 4 weeks, or who have new loss of sensation or movement above their injury level that has not yet been assessed by a doctor
• People with severe muscle stiffness (rated at level 4 on a standard medical scale)
• People who are unable to tolerate being upright for at least 10 minutes due to a drop in blood pressure
• People with uncontrolled autonomic dysreflexia (a condition affecting automatic body functions, common in spinal cord injury)
• People who are medically unstable
• People with an unstable heart or circulation condition, uncontrolled high blood pressure, a blood clot in a deep vein (DVT), or uncontrolled autonomic dysreflexia
• People with serious other health conditions that the trial investigator considers unsuitable for using the exoskeleton device or completing the study
• People with pressure sores or skin wounds of any grade in areas where the device would make contact with the body
• People whose height is outside the range of 1.5 to 1.9 metres, or who weigh more than 100 kg
• People with physical body characteristics (such as a significant difference in leg length) that make it impossible to fit or use the device safely
• People with joint movement limitations that prevent normal walking or sitting-to-standing movements, including restricted movement at the ankle, knee, or hip (confirm specific degree requirements with trial site)
• People with abnormal bone growth in soft tissue (a condition called heterotopic ossification)
• People who are pregnant or breastfeeding
• People with cognitive difficulties that prevent them from following simple instructions or completing study procedures
• People who require assisted breathing (mechanical ventilation)
• People with a significant spinal curvature (scoliosis) above a certain degree (confirm with trial site)
• People who have a pacemaker, defibrillator, or other electronic implant that is not compatible with the study device
• People with open wounds, infections, or active skin irritation at the sites where electrodes would be placed
• People with severe skin conditions in the areas where stimulation would be applied
• People with active epilepsy that is not well controlled
• People with a malignant tumour (cancer) in the area where the device would be applied
• People with severe loss of sensation in the areas where electrodes would be placed
• People whose doctor considers electrical stimulation to be medically inadvisable for them
• People who are unable to communicate pain, discomfort, or any adverse reactions during stimulation
• People with venous blood clots, inflammation of the veins, or severe blockage of arteries
• People with chronic vein problems with significant varicose veins
• People with haemophilia (a blood clotting disorder)
• People with an ongoing infection or fever
• People who have metal implants in the area through which the electrical current from the electrodes would pass

Important: Always verify eligibility with the trial site directly before applying.