Phase 2 Uveitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are able to understand the trial procedures, are willing to take part, can communicate with the research team, and are able to follow all study requirements, including signing a consent form.
• You are between 18 and 70 years old (inclusive) at the screening visit.
• At the screening visit, your Body Mass Index (BMI) is between 18 and 30, and you weigh at least 50 kg (if male) or at least 45 kg (if female).
• At least one of your eyes has been diagnosed by the study doctor with active non-infectious uveitis (inflammation inside the eye that is not caused by infection), specifically of the middle, back, or whole eye.
• Your eye condition is still active despite taking a steady dose of steroid tablets (such as prednisone) for at least 2 weeks, shown by at least one of the following: active inflammatory lesions in the back of the eye, significant inflammation in the front chamber of the eye, or significant cloudiness in the jelly-like substance inside the eye.
• You and your partner agree not to try to have a baby, or donate sperm or eggs, from the start of the trial until at least one month after your last dose of the study drug, and you agree to use an effective form of contraception during this time.

Who may not be able to join:

• You have uveitis that only affects the front part of the eye (anterior uveitis only).
• The only sign of your uveitis is swelling at the centre of the back of the eye (macular oedema), with no other signs of inflammation.
• You have uveitis caused by an infection, such as tuberculosis, cytomegalovirus, Lyme disease, toxoplasmosis, or certain other infections.
• You have a condition called Histoplasmosis Syndrome affecting the eye.
• Your eye condition is caused by something other than true inflammation, such as injury, cancer (including lymphoma), or previous surgery (confirm with trial site).
• You have a specific eye condition called serpiginous choroidopathy.
• You have cloudiness of the cornea or lens in either eye that makes it hard to examine the back of the eye, or that is likely to need cataract surgery during the trial.
• You have severe cloudiness of the jelly-like substance inside the eye, or any other problem that makes it impossible to see the back of the eye clearly in either eye.
• You have poorly controlled glaucoma (high pressure in the eye of 25 mmHg or more), are already using two or more glaucoma medications, or have signs of damage to the optic nerve from glaucoma.

Important: Always verify eligibility with the trial site directly before applying.