Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old (inclusive)
• You have been diagnosed with acute myeloid leukemia (AML), but not the subtype called "M3" (also known as APL)
• Your AML meets at least one of these situations: your leukemia did not go into remission after standard chemotherapy; your remission lasted 12 months or less; your remission lasted more than 12 months but the leukemia came back and at least one further chemotherapy treatment did not work; or your leukemia has relapsed after two or more previous treatments
• You are generally well enough to carry out light activity or self-care (your doctor will assess this using a standard scale)
• Your doctors estimate you have a life expectancy of at least 3 months
• Your heart is pumping well enough (confirmed by an ultrasound scan of the heart)
• Your kidneys are working well enough (confirmed by blood tests)
• Your liver is working well enough (confirmed by blood tests)
• Your oxygen levels are satisfactory when breathing normal room air
• You are able to swallow tablets or capsules and follow the study requirements
• You are willing to take part and sign a consent form

Who may not be able to join:

• You have a known allergy or sensitivity to any of the study drugs or their ingredients
• Your leukemia is currently active in your brain or spinal fluid (though people who previously had this but are now in stable remission may still be eligible — confirm with trial site)
• You have an active infection (bacterial, viral, or fungal) that is not under control
• You have a known inherited condition that affects bleeding or blood clotting, a history of bleeding episodes not caused by injury, or blood clots in your veins or arteries
• You have an active hepatitis B infection with detectable virus in your blood
• You have hepatitis C antibodies and detectable hepatitis C virus in your blood
• You are HIV positive
• You have tested positive for syphilis
• You are currently experiencing significant bleeding, have had a serious bleeding episode in the 4 weeks before joining, or have a known inherited bleeding disorder such as haemophilia
• You have serious heart problems, including severe heart failure, a heart attack or major heart surgery within the past 6 months, significant irregular heart rhythms, or severe disease of the heart muscle
• You have another cancer diagnosis, past or present (with the exception of certain treated skin cancers or early-stage cervical changes — confirm with trial site)
• You have a significant brain or nervous system condition, such as epilepsy, previous stroke, or a psychiatric disorder, that could affect your ability to safely take part
• You have taken part in another interventional clinical trial within the last 30 days
• You are pregnant, breastfeeding, or planning to become pregnant during the study or within 6 months after finishing, and are unwilling to use effective contraception
• You have a known or suspected problem with drug misuse or alcohol dependence
• You need to take certain medications that strongly affect how the study drug is processed by the body and these cannot be stopped or adjusted (confirm with trial site)
• Your doctor believes there is any other reason that taking part would not be safe or appropriate for you

Important: Always verify eligibility with the trial site directly before applying.