Printed from Voxsanity (voxsanity.com.au) — NCT07569419 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.
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Early Phase 1 Cystic Fibrosis Trial, Recruiting
NCT07569419
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are willing and able to give their agreement to take part after being fully informed about the study
- People aged between 18 and 60 years
- People who are not currently taking any medications, apart from certain antidepressants (SSRIs or low-dose tricyclic antidepressants), antihistamines, or the oral contraceptive pill
- People who are able to follow the study requirements, which include fasting overnight, following food and lifestyle rules, taking the study medication or a dummy version of it, having an MRI scan, eating a rice pudding meal containing blue dye, and keeping track of toilet visits and stool appearance
Who may not be able to join:
- People who cannot have an MRI scan — for example, those with metal implants, a pacemaker, a history of metal in the eye(s), a penetrating eye injury, or who are unable to lie still and flat for less than 5 minutes
- People who are pregnant, breastfeeding, or planning to become pregnant during the study
- People with a known pre-existing gut or bowel condition that may affect how the bowel works
- People who have previously had surgery to remove part of the food pipe, stomach, or intestine (not including the appendix)
- People who have a stoma (a surgically created opening from the bowel through the abdomen)
- People with a medical condition that could affect their ability to take part — for example, a known intolerance to rice pudding, or a known reason why taking linaclotide or the dummy medication would not be safe (confirm with trial site)
- People whose body mass index (BMI) is below 18.5 or above 35
- People who are not willing to follow the required food and lifestyle rules during the study
- People who are unable to stop taking certain medications that are known to affect how the gut moves — including mebeverine, opioids, certain antidepressants (MAOIs), phenothiazines, benzodiazepines, or calcium channel blockers — for the full duration of the study
- People who are currently taking, or have taken in the past 3 months, antibiotics or probiotics, as these may affect gut function
- People who have done night shift work (defined as working between midnight and 6:00 AM) in the week before their study day
- People who, in the opinion of the research team, are unlikely to be able to follow the study requirements — for example, due to cognitive difficulties or lifestyle factors related to substance use
- People who have taken part in another research study within the last 3 months that involved invasive procedures or a participation payment
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Early Phase 1 studies are small, early exploratory studies that come before the main Phase 1 to 3 testing, so a standard phase success rate does not apply.
Contact this trial
Phone: 07342646598
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
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Trial details
Status
Recruiting
Phase
Early Phase 1
Sponsor
University of Nottingham
Registry
ClinicalTrials.gov
Start date
9 March 2026
Est. completion
1 August 2026
Where this trial is recruiting
🇬🇧 United Kingdom
Primary endpoints
Small bowel water content
Can't join this trial?
Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.