Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be willing and able to give written consent before starting any treatment; if you have a history of serious psychiatric illness, your family must also give their consent
• You must be between 18 and 80 years old at the time of signing the consent form
• You must be generally well enough to carry out light activity and care for yourself (confirm with trial site what this means for your situation)
• You must have at least one area of cancer that can be measured on a scan, and that can be biopsied
• Your kidney cancer must be confirmed as "clear cell" type through a tissue sample
• You must fall into one of three groups based on how far your cancer has spread: early-stage (localised) kidney cancer meeting certain size or location criteria; locally advanced kidney cancer that has grown into nearby tissue or nearby lymph nodes; or kidney cancer that has spread to other parts of the body, where surgery to remove the kidney is still considered appropriate and your other cancer deposits are not larger than the main kidney tumour
• You must not have received any previous cancer treatment of any kind
• Your blood counts, kidney function, liver function, and certain heart-related blood markers must all be within acceptable ranges on blood tests

Who may not be able to join:

• You have cancer that has spread to your brain, or a scan shows signs of brain involvement
• You have had another type of cancer in the last 5 years, unless it was a type considered fully cured (such as certain skin cancers, early cervical changes, or treated thyroid cancer — confirm with trial site)
• You have previously been treated with immune checkpoint inhibitor drugs, experimental drugs, or experimental devices
• You have had major surgery within 4 weeks before starting the trial, are still recovering, or cannot have a biopsy done
• You have a history of severe allergic reactions to medications, including antibody-based drugs
• You have previously had serious immune-related side effects from treatment, such as immune-related heart inflammation, severe liver inflammation, severe lung inflammation, serious nerve problems, severe skin blistering, or severe eye inflammation (confirm with trial site which specific conditions apply)
• You have previously had an organ transplant or bone marrow/stem cell transplant from a donor, or you take long-term steroid medication
• You still have unresolved side effects from a previous cancer treatment that have not returned to near-normal levels
• You have a known significant liver disease, including active hepatitis B or C infection, or moderate-to-severe liver scarring (cirrhosis)
• You have fluid build-up in your chest, abdomen, or around your heart that needs to be regularly drained
• You have been taking steroid tablets (above a low dose) or other immune-suppressing medicines within the 14 days before starting the trial
• You have poorly controlled high blood pressure, recent heart attack or heart surgery, significant heart rhythm problems, reduced heart pumping function, or poorly controlled diabetes
• You have significant protein in your urine confirmed by a 24-hour urine test
• You have a severe active or uncontrolled infection
• You have an active autoimmune disease (such as lupus, rheumatoid arthritis, or inflammatory bowel disease)
• You require dialysis for kidney failure
• You have a known immune deficiency condition, including HIV
• You have received a live vaccine within 4 weeks before starting the trial, or plan to during the study
• You have a history of drug abuse or a mental health condition that you are unable to manage
• You are a woman who could become pregnant and do not have a negative pregnancy test or are not using appropriate contraception
• You have any other serious medical condition or abnormal test result that, in the doctor's judgement, could increase your risk or affect the trial results

Important: Always verify eligibility with the trial site directly before applying.