Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 years or older
• People with a body mass index (BMI) of 27 or above at the time of screening, who have tried dieting to lose weight without success
• People who have not been diagnosed with diabetes
• People who are able to read, understand, and sign a consent form
• People who are able to have a DEXA scan (a type of body composition scan)

Who may not be able to join:

• People with a history of type 1 or type 2 diabetes
• People whose body weight has changed by more than 5 kg (11 lbs) in the 90 days before screening, based on their own report
• People who have taken any medication for weight loss in the 90 days before screening
• People who have had, or are planning to have, weight-loss surgery or a weight-loss device during the trial period (some past procedures may be allowed if completed more than 1 year before screening — confirm with trial site)
• People with an uncontrolled thyroid condition, based on a blood test result outside the accepted range at screening
• People who have had a diagnosis of major depression within the past 2 years
• People who have been diagnosed with a severe psychiatric condition such as schizophrenia or bipolar disorder
• People who score 15 or higher on a standard depression questionnaire (called the PHQ-9) at screening
• People who have ever attempted suicide at any point in their life
• People who have shown suicidal behaviour in the 30 days before screening
• People who have used certain non-herbal traditional medicines with unknown ingredients within the past 90 days before screening
• People who have had acute pancreatitis (sudden inflammation of the pancreas) in the 180 days before screening
• People with a history of ongoing (chronic) pancreatitis
• People who, or whose close blood relatives, have a personal history of a condition called multiple endocrine neoplasia type 2 or medullary thyroid cancer
• People with severely reduced kidney function, based on a blood test at screening
• People who have been diagnosed with cancer in the past 5 years (certain minor skin cancers may be allowed — confirm with trial site)
• People who have had a heart attack, stroke, unstable chest pain requiring hospitalisation, or a mini-stroke (transient ischemic attack) in the 60 days before screening
• People who have been classified as having the most severe level of heart failure (New York Heart Association Class IV)
• People who have a major surgery planned during the trial period (minor procedures may be acceptable — confirm with trial site)
• People with known or suspected alcohol or recreational drug misuse
• People who are known to be allergic or sensitive to the trial treatment or similar products
• People who have previously signed a consent form for this same trial
• People who have taken part in another clinical trial within 90 days before screening
• Women who are pregnant, breastfeeding, planning to become pregnant, or who are able to become pregnant and are not using a highly effective form of contraception
• People whose circumstances or health conditions, in the opinion of the trial doctor, could put their safety at risk or affect their ability to follow the trial requirements (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.