Phase 1 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose overall health and ability to carry out daily activities falls within a certain range, measured by a standard scale called ECOG, with a score of 0 (fully active) or 1 (restricted in strenuous activity but able to do light work).
• People who have been confirmed by laboratory tissue testing to have a type of cancer that cannot be removed by surgery — either Stage III or Stage IV melanoma (a type of skin cancer), or another solid tumour.
• People whose cancer has stopped responding to standard treatments (including targeted therapies), who are unable to tolerate standard treatments, or who have chosen not to pursue standard treatments.
• People whose cancer can be measured using standard imaging criteria (known as RECIST v1.1), meaning the tumour(s) are visible and trackable on scans.
• People whose tumour has one or more confirmed mutations in a gene called NRAS, which is known to drive cancer growth.

Who may not be able to join:

• People whose cancer has a known mutation in certain other genes (KRAS, HRAS, or BRAF), or known changes in other genes that drive cancer growth.
• People who have previously been treated with certain types of drugs that target the RAS-MAPK pathway — a signalling system involved in cancer cell growth — including drugs targeting ERK, MEK, RAF, or RAS.
• People with melanoma who have a blood test result showing a protein called LDH at more than twice the upper limit of the normal range.
• People who have cancer that has spread to the brain or spinal cord and is causing worsening neurological symptoms, or who need ongoing steroid medication to manage that spread.

Important: Always verify eligibility with the trial site directly before applying.