Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old
• People who have been diagnosed with a specific type of cancer called squamous cell carcinoma in the head and neck area (such as the mouth, throat, voice box, or lower throat), at an advanced but not the most severe stage (Stage III to IVB)
• People whose cancer has been assessed by a specialist team — including surgeons, radiologists, and pathologists — and considered suitable for surgical removal
• People who are generally well enough to carry out light activity and care for themselves, with only minor limitations on physical activity (this is measured on a standard scale called ECOG, scores 0 or 1)
• People with throat cancer in a specific location (oropharynx) who have had, or are able to have, a particular protein test called p16 carried out on their tumour
• People who have tumour tissue available (either stored from a previous procedure or newly collected) for a protein test called PD-L1
• People who have at least one tumour that can be measured on a scan
• People with a life expectancy of at least 6 months
• People whose blood counts, kidney function, and liver function fall within the acceptable ranges required by the trial (the trial site will check these through blood tests)
• Women who are not pregnant and not breastfeeding, and who agree to use highly effective contraception during the trial and for 6 months after the last dose
• Men who agree to use highly effective contraception during the trial and for 6 months after the last dose
• People who are willing to give written consent and attend all required trial visits

Who may not be able to join:

• People who have received certain cancer treatments — including PD-1 inhibitors, EGFR antibodies, EGFR-targeted therapies, or anti-blood-vessel growth drugs — within the 4 weeks before joining
• People who have taken part in another interventional clinical trial within the past 30 days
• People who, in the treating doctor's judgement, cannot safely receive platinum-based chemotherapy (cisplatin or carboplatin)
• People whose cancer cannot be surgically removed, who are not medically well enough for surgery, who decline surgery for any reason, or whose tumour is too large to be removed
• People who have had another cancer diagnosed within the past 5 years, except for a common and easily treated type of skin cancer called basal cell carcinoma
• People with a history of a condition that causes the immune system to not work properly from birth or early life (primary immunodeficiency)
• People with serious ongoing health conditions that are not well controlled, such as heart failure, severe lung disease, severe liver disease, or significant mental health conditions
• People with a known HIV infection, active hepatitis B or C, or active tuberculosis
• People who have had major surgery within the past 90 days, or who are planning major surgery unrelated to this cancer
• People who have a known allergy or sensitivity to any of the drugs used in the trial
• Women who are pregnant or breastfeeding, or people of childbearing potential who are unwilling or unable to use effective contraception during the trial and for at least 6 months after the last dose
• People who, in the treating doctor's judgement, are not suitable for the trial for any other reason
• People who are unwilling to participate or unable to give written consent
• People who have received a live vaccine within 30 days before the first trial treatment

Important: Always verify eligibility with the trial site directly before applying.