Phase 1 Lupus Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 75 years old at the time of screening
- You have a minimum level of certain immune cells (B-cells) in your blood at the start of the trial (confirm with trial site)
If you have Lupus (SLE), you may also need to meet these requirements:
- You have been formally diagnosed with SLE and meet recognised international classification standards for the condition
- Specific blood tests show a positive result for certain immune markers linked to lupus (confirm with trial site)
- Your lupus disease activity score meets a minimum threshold based on a standard medical assessment tool (confirm with trial site)
- At least one medication used to suppress the immune system has not worked well enough for you, and you took it for at least 3 months
If you have Rheumatoid Arthritis (RA), you may also need to meet these requirements:
- You have been formally diagnosed with RA and meet recognised international classification standards for the condition
- Specific blood tests show certain markers associated with RA are above normal levels (confirm with trial site)
- You currently have at least 6 swollen joints and 6 tender joints
- A blood inflammation marker called CRP is at or above a certain level (confirm with trial site)
- At least one standard RA medication and at least one biological or targeted RA medication have not worked well enough for you
Who may not be able to join:
- You have a history of infection (confirm with trial site for details on type or severity)
- You have high blood pressure that is not well controlled
If you have Lupus (SLE):
- You currently have, or have had in the last 6 months, lupus affecting your brain or nervous system (though lupus headaches may be allowed — confirm with trial site)
- You have active or worsening lupus affecting your kidneys in a serious way (confirm with trial site)
- You have been diagnosed with lupus alongside another related autoimmune condition, such as RA, Sjogren's disease, or others in this group
If you have Rheumatoid Arthritis (RA):
- You have been diagnosed with RA alongside another related autoimmune condition, such as lupus, Sjogren's disease, scleroderma, or others in this group
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: ABBVIE INC., AbbVie
Phone: 844-663-3742
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change from Baseline in B Cells in Blood; Maximum Plasma Concentration (Cmax) of ABBV-519.; Time to Cmax (Tmax) of ABBV-519; Terminal Phase Elimination Half-Life (t1/2) of ABBV-519; Area Under the Concentration-Time Curve From Time 0 to Last Measurable Concentration (AUCt) of ABBV-519; Percentage of Participants with Detection of Anti-Drug Antibodies (ADAs) for ABBV-519; Number of Participants with Adverse Events (AEs)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.