Lupus

**Who might be able to join this trial:** - You are 16 years of age or older (male or female) - You have been diagnosed with lupus (SLE) for at least six months, meeting at least 4 out of 11 standard lupus diagnostic criteria - Your lupus is currently active and flaring in a way that requires a change in your steroid m...

**Who might be able to join this trial:** - Your blood test at the screening visit shows a positive result for antinuclear antibodies (ANA), which are markers found in certain autoimmune conditions - You have been formally diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) and meet at least 4 out of 11 recognised...

**Who might be able to join this trial:** - You previously took part in one of the related studies (SL0009 or SL0010) and either finished it, or left at week 16 or later because the treatment wasn't working well enough — and your doctor thinks you could still benefit from continuing the treatment - You previously comp...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) based on recognised medical guidelines. - Your lupus is currently active (meaning you are experiencing symptoms or flares). - Your blood tests show certain antibodies linked to lupus (confirm with trial sit...

**Who might be able to join this trial:** - You must have already taken part in and completed one of two specific earlier studies (D3461C00004 or D3461C00005), receiving either the study drug (anifrolumab) or a placebo for the full 52-week treatment period - You must have suitable veins that allow for an intravenous d...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE), commonly known as lupus, for at least 24 weeks before the screening visit. - Your lupus diagnosis meets a specific set of recognized international classification guidelines for lupus (confirm with trial site). -...

**Who might be able to join this trial:** - Both men and women may be eligible to participate. - Women who could become pregnant and men who could father a child must be willing and able to use two reliable forms of birth control at the same time (at least one must be highly effective), starting before the trial medic...

**Who might be able to join this trial:** - You are between 18 and 75 years old at the time of your screening visit. - You have agreed to take part and given your consent before any study activities begin. - You have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) according to specific 2019 medical guidel...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE, also known as lupus) for at least 24 weeks before the screening visit. - Your diagnosis meets at least 4 out of 11 specific criteria used by doctors to officially classify lupus, based on a widely recognised medi...

**Who might be able to join this trial:** - You have active skin lupus (a type called SCLE or DLE) with a skin disease activity score of 8 or higher on a specific measurement scale called CLASI-A. - You have active lupus (SLE) with a skin activity score of 8 or higher, along with other measures of lupus activity reachi...

**Who might be able to join this trial:** - People who have been diagnosed with Systemic Lupus Erythematosus (lupus/SLE), confirmed by meeting specific medical classification standards — either at least 4 out of 11 criteria from a 1997 checklist, or at least 4 out of 17 criteria from a 2012 checklist (with certain comb...

**Who might be able to join this trial:** - You must sign a consent form before joining; if you are under 18, a parent or legal guardian must also sign, and you may need to give your own agreement depending on your age and local rules. - You must have already taken part in one of two specific related studies (called CV...

**Who might be able to join this trial:** **General requirements (all participants):** - Adults aged 18 to 75 years old - Willing and able to sign a consent form and follow the study schedule and requirements - Women who could become pregnant must have a negative pregnancy test at the start of the study and agree to u...

**Who might be able to join this trial:** **If you have Lupus (SLE) — Subprotocol A or B:** - You have been diagnosed with SLE (lupus) based on 2019 international classification guidelines. - You have tested positive for at least one specific lupus-related antibody (ANA, anti-dsDNA, or anti-Smith) either at screening...

Who might be able to join this trial: - Adults aged 18 to 75 years (inclusive) who have been diagnosed with Systemic Lupus Erythematosus (SLE, a chronic autoimmune disease) based on recognised international classification standards. - People whose blood tests show certain markers of lupus activity — specifically, a pos...

**Who might be able to join this trial:** - You have been diagnosed with lupus (SLE) for at least 24 weeks before the screening visit, and your diagnosis meets specific classification guidelines. - You have had at least one of certain lupus-related proteins (autoantibodies) detected in your blood — either a positive A...

**Who might be able to join this trial:** **Part A (Healthy Volunteers):** - You fully understand what the study involves and are willing to sign a consent form to participate - You are a healthy man or woman between 18 and 55 years old, and your body weight falls within an acceptable range for your height (confirm wi...

Who might be able to join this trial: - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) and/or Rheumatoid Arthritis (RA), confirmed using standard international classification guidelines. - People whose disease is currently active enough to meet specific scoring thresholds measured at the screen...

**Who might be able to join this trial:** - People aged 18 to 70 years old at the time of giving consent. - People who are willing and able to attend all required study visits and follow the study requirements. - People whose liver, kidneys, lungs, and heart are functioning adequately. - People who have been formally...

Who might be able to join this trial: **For people with Systemic Lupus Erythematosus (SLE) — a disease where the immune system attacks the body:** - You have been diagnosed with SLE based on specific medical guidelines (2019 ACR/EULAR criteria) - Certain specific antibodies related to SLE were found in your blood duri...

Who might be able to join this trial: **Healthy volunteers:** - You are between 18 and 55 years old and considered to be in good health. - You weigh at least 50 kg (about 110 lbs) and your body mass index (a measure of body weight relative to height) is between 18 and 32. **People with Systemic Lupus Erythematosus (S...

**Who might be able to join this trial:** - Adults aged 18 to under 75 years (the minimum age may vary slightly depending on local rules about what counts as adulthood) - People who have been formally diagnosed with Systemic Lupus Erythematosus (SLE — a chronic immune system disease) at least 24 weeks before the scree...

Who might be able to join this trial: - You are in generally stable health based on a physical exam, medical history, vital signs, and heart tracing (ECG) done at the screening visit. - You have been diagnosed with systemic lupus erythematosus (SLE/lupus) for at least 24 weeks before the screening visit, using recognis...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) according to recognised medical guidelines (2019 ACR / 2023 EULAR criteria) - Your lupus is currently moderately or highly active, based on standard scoring tools used by your doctor - If you have lupus ne...

Who might be able to join this trial: - You must have completed Week 52 of a previous related study called Study 211LE201 (NCT01499355) without stopping your assigned treatment (either the study drug or placebo). - If you are someone who could become pregnant, you must be willing and able to use effective birth control...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) for at least 24 weeks before the screening visit. - Your diagnosis meets at least 4 out of 11 specific classification criteria for lupus, as defined by a major rheumatology organization (confirm with trial...

Who might be able to join this trial: - You must have already completed the final treatment visit in one of the qualifying previous studies (either study JAHZ or study JAIA). Who may not be able to join: - There are no specific exclusion criteria listed in the official information provided (confirm with trial site)....

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE, also called Lupus) based on a specific set of recognised medical standards. - A kidney biopsy has confirmed that you have an active form of Lupus Nephritis (kidney inflammation caused by Lupus) of a certain type...

Who might be able to join this trial: - People who have been diagnosed with, or are suspected to have, lupus (SLE), based on recognised medical classification criteria - People who are able to give their own informed consent to participate - Close blood relatives (parents, children, brothers, sisters, grandparents, aun...

**Who might be able to join this trial:** - You are pregnant with a confirmed live pregnancy inside the womb, no more than 12 weeks along (or up to 18 weeks if you have certain antibodies called antiphospholipid antibodies) - You are between 18 and 45 years old and can agree to participate yourself, or you are under 1...

Who might be able to join this trial: - People who have been diagnosed with Systemic Lupus Erythematosus or Cutaneous Lupus (types of lupus affecting the whole body or the skin) - People who are currently a patient of a rheumatologist (a joint and immune system specialist) at Duke University Medical Center Who may not...

Who might be able to join this trial: - People aged 2 years or older - People who identify as African-American "Gullah" from the Sea Island region of South Carolina - People who have been diagnosed with lupus (SLE) meeting at least 4 out of 11 specific criteria set by the American College of Rheumatology, OR who are a...

Who might be able to join this trial: - You are male or female, aged 18 or older - You are willing and able to give your consent to take part in the study - You need a kidney biopsy for medical reasons (Native Biopsy Tissue Group) - You have previously had a kidney biopsy but your tissue sample is not stored in this re...

Who might be able to join this trial: - People who have been diagnosed through a biopsy with a specific type of lupus-related kidney disease (called Class III, IV, or V lupus nephritis), and who are currently showing signs of active kidney inflammation, such as significantly increased protein in their urine or a notabl...

"Who might be able to join this trial: - People who have been diagnosed with lupus nephritis (a kidney condition caused by lupus) Who may not be able to join: - No exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility with the trial site directly before appl...

Who might be able to join this trial: - You are a woman who is currently pregnant or planning to become pregnant within the next 6 months - You have been diagnosed with an autoimmune condition such as Lupus, Rheumatoid Arthritis, Scleroderma, Sjögren's Syndrome, Antiphospholipid Syndrome, Inflammatory Arthritis (includ...

Who might be able to join this trial: - You are 18 years of age or older - You are willing to sign a consent form agreeing to take part in the study - You have been diagnosed with a rheumatoid condition (a type of inflammatory joint disease, such as rheumatoid arthritis) Who may not be able to join: - No specific excl...

**Who might be able to join this trial:** - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) according to standard medical criteria. - People whose SLE diagnosis was made within the last 2 years before the screening visit. - People whose blood tests show a positive A...

**Who might be able to join this trial:** - You are 18 years of age or older and are willing to sign a consent form to take part. - You have been diagnosed with systemic lupus erythematosus (SLE), a condition where the immune system attacks the body's own tissues, confirmed by meeting standard medical criteria. - You...

Who might be able to join this trial: - You are suspected of having a kidney disease affecting the filtering units of the kidney (called glomerular disease) and have had a kidney biopsy performed at one of the participating hospital centers - Children under 18 years old may also be eligible to join Who may not be able...

Who might be able to join this trial: - Adults (over 18 years old), either women or men, who are attending the multidisciplinary consultation in Brest, France - People who have given their written agreement to take part in the trial Who may not be able to join: - People who are under 18 years old - People who do not w...

**Who might be able to join this trial:** - People who have been formally diagnosed with Systemic Lupus Erythematosus (SLE) according to recognised international classification standards - People who are 18 years of age or older - People who have a newly diagnosed form of lupus kidney disease (lupus nephritis), confir...

Who might be able to join this trial: - People who are older than 18 years of age. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) confirmed using one of the recognised medical classification systems (known as ACR, SLICC, or ACR/EULAR criteria). - People diagnosed with SLE at any point in...

**Who might be able to join this trial:** - People aged 14–17 years old (children/teenagers) or adults - People with active lupus nephritis (lupus affecting the kidneys) confirmed by a kidney biopsy taken within the past 8 weeks, showing a specific level of kidney inflammation as classified by an international kidney...

Who might be able to join this trial: - People who are 5 years of age or older at the time of screening. - People who have a confirmed diagnosis of Juvenile Idiopathic Arthritis (JIA), Lupus (SLE), or Fibromyalgia (FM), supported by their medical history. Who may not be able to join: - People who have a documented his...

Who might be able to join this trial: **For patients:** - Children and young people under 18 years old who have health insurance - People being treated at Necker hospital for a primary immune deficiency (a condition where the immune system doesn't work properly) combined with autoimmune or inflammatory conditions — su...

**Who might be able to join this trial:** - You have been diagnosed with systemic lupus erythematosus (SLE), confirmed using standard medical criteria - You are pregnant and between 20 and 45 years old - You are willing to take part in the study, follow the treatment plan, attend follow-up appointments, and sign a cons...

Who might be able to join this trial: - You must be 18 years old or older - You must have been diagnosed with interstitial lung disease (a type of lung condition causing scarring or inflammation), confirmed by a CT scan of the chest - You must have either a defined autoimmune/connective tissue disease, an early or uncl...

**Who might be able to join this trial:** - You are between 8 and 25 years old at the time of joining the trial - You have been diagnosed with severe systemic sclerosis or severe systemic lupus erythematosus (a serious autoimmune disease), meeting specific medical criteria (confirm with trial site) - Your major organs...

**Who might be able to join this trial:** - You are between 12 and under 18 years old at the time of joining the trial (a younger group for children aged 5 to under 12 may also open later — the trial site can advise on this) - A kidney biopsy taken in the last 12 months (or during screening) shows a specific type of a...

Who might be able to join this trial: **For people with suspected glandular fever (infectious mononucleosis):** - You are willing to give your signed consent to take part - A doctor has confirmed you have a current EBV (Epstein-Barr virus) infection for the first time - You have symptoms consistent with glandular feve...

**Who might be able to join this trial:** - You must be 18 years old or older - You must weigh at least 40 kg (about 88 pounds) - You must have valid health insurance - You must have been diagnosed with lupus according to specific 2019 international guidelines (confirm with trial site) - You must have active lupus that...

**Who might be able to join this trial:** - You are 18 years of age or older. - You have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) using recognised medical guidelines. - A urine test has shown a certain level of protein in your urine (confirm with trial site), measured from a 24-hour urine sample tak...

Who might be able to join this trial: - You are between 18 and 80 years old - You have been diagnosed with systemic lupus erythematosus (lupus/SLE) based on recognised medical guidelines - You have been diagnosed with a specific type of kidney inflammation caused by lupus (called proliferative lupus nephritis, class II...

**Who might be able to join this trial:** - You have had a blood test showing positive results linked to lupus (called ANA and/or anti-dsDNA tests). - You have been diagnosed with a specific type of kidney inflammation caused by lupus (called lupus nephritis Class III or IV, with or without Class V), confirmed by a ki...

**Who might be able to join this trial:** - You have been diagnosed with lupus (a condition called Lupus Erythematosus Disseminatus, or LED) based on recognised medical guidelines (ACR/EULAR 2019), in any form, whether your condition is currently calm or in a flare-up - Your blood tests show positive anti-DNA antibodie...

**Who might be able to join this trial:** - People aged between 18 and 80 years old - People who are in good general health, or who have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) using a recognised set of medical classification standards - People willing to sign a consent form and take part in all p...

Who might be able to join this trial: - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) according to standard international classification guidelines. - People who are 18 years of age or older. - People who have a new or returning case of lupus nephritis (lupus-related kidney disease) that has be...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) based on recognised medical guidelines - You were diagnosed with SLE less than 5 years ago - You are willing and able to sign a consent form agreeing t...

**Who might be able to join this trial:** - You are expected to need a kidney transplant because of a genetic or immune system disease (such as SIOD, FSGS, Cystinosis, Lupus/SLE, certain types of kidney inflammation, or other genetic conditions causing kidney disease), OR because your body previously rejected a kidney...

**Who might be able to join this trial:** - You are between 8 and 20 years old (male or female) - You have been diagnosed with Systemic Lupus Erythematosus (SLE, sometimes called "lupus") according to standard medical guidelines - You have been diagnosed with a specific type of kidney disease related to lupus (called...

**Who might be able to join this trial:** - People who are willing and able to give informed consent before any study procedures begin - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) based on a specific set...

Who might be able to join this trial: - Women with lupus (SLE) who were under 40 years old when they started cyclophosphamide (CYC) treatment, and who did not receive a hormone-protecting injection called GnRH-a alongside it (Group 1) - Women with lupus (SLE) who were under 40 years old when they started cyclophospham...

**Who might be able to join this trial:** - You are between 18 and 75 years old (inclusive) - You have been diagnosed with systemic lupus erythematosus (lupus) based on recognised medical guidelines - You have an active form of lupus that affects the kidneys (called lupus nephritis), confirmed by a kidney biopsy taken...

**Who might be able to join this trial:** - You fully understood the study and voluntarily signed a consent form agreeing to take part. - You are aged 18 to 75 years old (male or female). - You were diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) at least 6 months before signing the consent form, and your diagn...

Who might be able to join this trial: - People who are male or female - People aged between 18 and 60 years old - People who have been diagnosed with systemic lupus erythematosus (a type of autoimmune disease) according to recognised medical diagnostic guidelines - People who are covered by health insurance - People wh...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) based on recognised medical criteria - You are at least 18 years old - Your SLE is not currently in full remission — meaning your disease is still showing some level of activity, whe...

**Who might be able to join this trial:** - You are willing to sign a consent form and agree to follow all study requirements for the full length of the study - You are 60 years of age or older at the time of joining - You have had a normal eye scan (OCT) and visual field test within the last 6 months - You are able to...

**Who might be able to join this trial:** - A parent, caregiver, or legal guardian must be able to give signed consent on the participant's behalf, and the participant themselves may also need to give consent depending on local rules. - The participant must have been diagnosed with Systemic Lupus Erythematosus (SLE —...

**Who might be able to join this trial:** - You are between 18 and 70 years old - You have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) and scored at least 10 points on a standard lupus classification scoring system - Your lupus has not been adequately controlled despite trying at least two immunosuppr...

Who might be able to join this trial: - People who are 18 years of age or older - People who have a confirmed diagnosis of systemic lupus, which may also involve related conditions such as antiphospholipid syndrome or Gougerot-Sjögren's syndrome (a condition affecting moisture-producing glands) - People with lupus who...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a chronic immune system disease), confirmed by recognized medical guidelines, and certain specific antibodies were found in your blood tests. - Your SLE is currently active, affecting at least one major organ, a...

**Who might be able to join this trial:** - You have been diagnosed with lupus (systemic lupus erythematosus) and your lupus has affected your kidneys (lupus nephritis), based on specific medical classification guidelines. - Your lupus has been well-controlled and stable for at least 6 months, meaning your urine prote...

**Who might be able to join this trial:** - People aged 18 to 65 years old (any gender) - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, also known as lupus) based on recognised 2019 international classification guidelines, with certain specific antibody markers present in their blood - People...

**Who might be able to join this trial:** - People aged 18 to 65 years old (male or female) who are willing to take part and sign a consent form - People who have previously been diagnosed with systemic lupus erythematosus (SLE), a type of autoimmune disease, based on a specific set of recognised diagnostic guidelines...

**Who might be able to join this trial:** **For people with lupus (SLE):** - Women aged 18 or older who have been diagnosed with lupus meeting specific criteria, and whose disease is mild to moderately active at the time of screening - If taking steroid medications, the dose must be no more than 20 mg per day and must...

**Who might be able to join this trial:** - You are willing to sign a consent form agreeing to take part voluntarily. - You are between 18 and 65 years old (male or female). - You have been diagnosed with lupus (SLE) meeting at least 4 out of 11 specific medical criteria, and your disease is currently considered moder...

**Who might be able to join this trial:** - People who are willing to give informed consent (or whose guardian gives consent on their behalf) and are able to attend all required visits, tests, and treatments throughout the study - Adults aged 18 to 70 years old, of any gender - People who weigh at least 40kg - People...

**Who might be able to join this trial:** - People who (or whose guardians) are able to understand and sign a consent form, and are willing to attend all required visits and follow all study procedures - People aged 18 to 70 years old, of any gender - People who weigh at least 40 kg (about 88 pounds) - People who were...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have been diagnosed with Systemic Lupus Erythematosus (SLE, or "lupus") based on recognised medical guidelines - A specific blood test (looking for certain antibodies linked to lupus) came back positive at the screening stage - If joi...

**Who might be able to join this trial:** - You have been diagnosed with lupus nephritis (lupus affecting the kidneys), confirmed by a kidney biopsy, specifically classified as Class III, IV, or V - You have chronic kidney disease with a kidney function level (eGFR) between 15 and 60 mL/min - Your lupus is currently in...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) — either through standard medical classification systems or by a doctor based on your symptoms - Your SLE is currently at a low to moderate level of a...

**Who might be able to join this trial:** - People aged between 16 and 60 years old - People who have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) according to a specific set of medical guidelines from 2012 - People who have had a kidney biopsy within the last 6 months showing a specific type of lupus-r...

Who might be able to join this trial: - People who have been diagnosed with systemic lupus erythematosus (lupus) for at least 6 months. - People who have been on a stable lupus treatment for at least 28 days before the first dose of the trial treatment. - People whose lupus disease activity falls within a specific rang...

**Who might be able to join this trial:** - People who are at least 18 years old. - People who have given written, signed, and dated consent before any trial procedures begin. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) — a disease where the immune system attacks the body — meeting a speci...

**Who might be able to join this trial:** - People who can read, write, and speak English - People who have internet access and the ability to join video or audio calls (such as Zoom) from home, either by phone or computer **For people with fibromyalgia, one of the following must apply:** - A doctor has diagnosed the...

**Who might be able to join this trial:** **As a participant:** - Women aged 18 or older who have a self-reported or documented diagnosis of Lupus or Lupus Nephritis - People who are willing to sign and date a consent form and follow all study procedures for the full length of the study - People who are willing to fol...

**Who might be able to join this trial:** - People who have been diagnosed with childhood-onset lupus (cSLE) before the age of 18, based on recognised classification guidelines - People who are between 12 and 22 years old - People who experience at least one of the following: notable fatigue, depressive symptoms, or pa...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus). - You are 18 years old or older at the time of signing up. - You have been experiencing fatigue as an ongoing problem for at least the past 4 weeks, and it has a significant impact on your quality of life...

Who might be able to join this trial: - You are 18 years old or older when you sign up for the study. - You have been diagnosed with Systemic Lupus Erythematosus (SLE, or lupus) based on recognised 2019 medical guidelines. - Your doctor has decided to prescribe you a medication called anifrolumab for your lupus for the...

**Who might be able to join this trial:** - You are willing and able to give your consent to take part (or a legal representative can do so on your behalf) - You are between 18 and 70 years old (inclusive), of any gender - You have been diagnosed with systemic lupus erythematosus (SLE) that has not responded well to s...

**Who might be able to join this trial:** - Adults aged 18 or older (in Spain) or people aged 12 to 65 (in the UK) at the time of joining the study - People who have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) based on recognised international classification guidelines - People whose blood tests show...

**Who might be able to join this trial:** - You are between 18 and 69 years old - You have been officially diagnosed with Systemic Lupus Erythematosus (SLE, a chronic autoimmune disease) using standard medical criteria - Your lupus is still active despite trying standard treatments such as steroids and hydroxychloroqu...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who are able to understand the study and are willing to sign a consent form, including consent for their data to be used - People whose kidneys, liver, heart, and lungs are functioning a...

**Who might be able to join this trial:** - The person joining (or their legal guardian) must be willing and able to sign a consent form and follow all study requirements, appointments, and treatments - Adults between 18 and 70 years old, of any gender - People who have been diagnosed with Systemic Lupus Erythematosus...

Who might be able to join this trial: - People who have been diagnosed with systemic lupus erythematosus (a long-term immune system condition) based on recognised international diagnostic standards from 1997 or 2019 - People who have been seen as an active patient in the internal medicine department at the Martinique U...

**Who might be able to join this trial:** - You are between 18 and 70 years old - You have been diagnosed with Systemic Lupus Erythematosus (SLE, or "lupus") that is currently in a low-activity state, based on specific scoring tools used by doctors, and you have had the condition for more than 3 months - Your lupus tr...

**Who might be able to join this trial:** - You are between 18 and 60 years old (any gender) - You were diagnosed with lupus (SLE) at least 24 weeks before signing the consent form, using recognized medical guidelines - Your lupus is currently active or has not responded well to previous treatments - At least one spec...

**Who might be able to join this trial:** - People aged 18 to 75 years old who are able to give written consent before any study procedures begin. - People who have previously been diagnosed with systemic lupus erythematosus (SLE) — a condition where the immune system attacks the body's own tissues — based on establis...

**Who might be able to join this trial:** - People who have been diagnosed with systemic lupus erythematosus (SLE, also known as lupus) within the last 2 years, based on recognised 2019 international classification guidelines. - People whose blood tests show certain lupus-related antibodies — specifically, a positive...

**Who might be able to join this trial:** **For people with Systemic Sclerosis (SSc / Scleroderma):** - People who have been formally diagnosed with SSc according to established medical classification criteria, with a positive ANA blood test at a certain level - People with the "diffuse" form of SSc whose disease star...

**Who might be able to join this trial:** **For patients:** - You are 18 years of age or older - You speak English and are able to give your own consent to participate - You have been diagnosed with lupus (SLE) and are being treated by a doctor who is taking part in this study - You have been prescribed at least one l...

Who might be able to join this trial: - You are between 18 and 70 years old (including those who are exactly 70) - You have been diagnosed with systemic lupus erythematosus (SLE, also known as lupus) based on recognised international diagnostic guidelines - You are receiving or plan to receive treatment with a medicine...

**Who might be able to join this trial:** - You are between 2 and 30 years old (note: the trial will start with people aged 17 and older, and may gradually open to younger ages after safety reviews) - You have Systemic Lupus Erythematosus (SLE/Lupus) that is still active in your blood and has not responded to other tr...

Who might be able to join this trial: - Children who meet the specific diagnostic criteria for the condition being studied (confirm with trial site for exact details) Who may not be able to join: - Children who have another rheumatological (joint, muscle, or immune-related) condition - Newborn babies (neonates) - Chil...

**Who might be able to join this trial:** - You are 18 years of age or older. - If your kidneys are affected, they must still be working at a minimum level (your doctor will check this with a kidney function test). - Your blood test results taken within 3 days before a key procedure must meet certain minimum levels fo...

**Who might be able to join this trial:** - Adults aged 18 or older. - People whose kidneys are affected must have kidney function at or above a certain level (an eGFR of at least 15 mL/minute/1.73 m²). - People whose blood test results, taken within 3 days before a specific cell collection procedure, meet minimum lev...

Who might be able to join this trial: - People aged 18 or older, of any gender, who are willing to sign a consent form - People whose bone marrow is producing enough blood cells — specifically, white blood cell counts, infection-fighting cells (neutrophils), and red blood cells (hemoglobin) must all meet minimum levels...

Who might be able to join this trial: - You have been diagnosed with systemic lupus erythematosus (SLE) using the 2019 international classification guidelines - You are between 18 and 65 years old - You weigh at least 40 kg (about 88 lbs) - Your SLE has remained active or gotten worse even after trying standard treatme...

**Who might be able to join this trial:** - You are willing and able to sign a consent form to take part in the study - You are male or female and aged 18 or older when you first started taking belimumab - You were prescribed belimumab (either as an injection under the skin or through a drip) to treat active lupus neph...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) for at least 12 weeks before the initial screening appointment - Your lupus is considered active enough to meet a specific disease activity score called SLEDAI-2000, with a score of...

"Who might be able to join this trial: - Adults aged 18 or older who are attending a multidisciplinary consultation (a medical appointment involving a team of different healthcare specialists) Who may not be able to join: - People who do not wish to participate or have expressed that they do not want to take part Imp...

**Who might be able to join this trial:** - People aged 18 to 70 years old (male or female) - People who were diagnosed with lupus (SLE) at least 24 weeks before the screening visit, and whose diagnosis meets a recognised international classification system for lupus - People whose lupus is currently active enough to m...

**Who might be able to join this trial:** - People aged 3 to 65 years, of any sex. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) according to the 2019 international classification standards set by EULAR and ACR. - People whose blood tests show certain specific markers of SLE activity (a posi...

Who might be able to join this trial: - People who were diagnosed with Systemic Lupus Erythematosus (SLE, a chronic autoimmune disease) before the age of 18, based on recognised international diagnostic guidelines - People who showed signs of kidney involvement (through symptoms, blood/urine tests, or kidney biopsy res...

**Who might be able to join this trial:** **For the mother:** - The mother is 18 years of age or older - The mother has given signed consent to take part in the study - The mother has been diagnosed with moderate or severe lupus (SLE) - The mother is currently being treated with a medicine called anifrolumab - The mot...

**Who might be able to join this trial:** - You are 16 years of age or older (18 or older if you are in China) at the time you sign the consent form - You have been diagnosed with Systemic Lupus Erythematosus (SLE — a chronic immune system disease) by a qualified doctor for at least 24 weeks before the screening visit...

**Who might be able to join this trial:** - You must be 18 years old or older. - You have been diagnosed with Systemic Lupus Erythematosus (SLE or "lupus") based on recognised international classification guidelines, or you are a healthy person being included for comparison purposes. - You are able to cooperate and ans...

Who might be able to join this trial: This trial has four different groups. A person may fit into one of the following: **Group 1 – People with lupus (SLE) and kidney involvement:** - Adults aged 18 or older - Diagnosed with lupus (SLE) based on recognised 2019 international classification criteria - Has positive aut...

**Who might be able to join this trial:** - People who are willing to take part in clinical research voluntarily - People aged between 18 and 65 years old - People who were diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) at least 6 months before the screening appointment - People whose b...

**Who might be able to join this trial:** - People who are able to understand the purpose and risks of the study and are willing to sign a consent form and follow study requirements - People aged 18 to 55 years old (male or female) - Men who weigh at least 50 kg, or women who weigh at least 45 kg, and whose body mass...

Who might be able to join this trial: **Group 1 (Exposed group – for people who have taken anifrolumab):** - You are currently pregnant or were pregnant within the last year - You have been diagnosed with moderate or severe lupus (SLE) - You are willing to give your consent to take part in the study - You agree to all...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) based on recognised medical classification systems. - You have been taking steroids together with immune-suppressing medications and/or biologic treatments for at least 2 months before the screening visit,...

**Who might be able to join this trial:** - People aged 18 to 65 years old, of any gender. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) according to the 2019 international diagnostic guidelines. - People in the lupus nephritis (kidney-related lupus) subgroup must have a specific type...

Who might be able to join this trial: - You have been diagnosed with lupus nephritis that was confirmed by a biopsy (a small tissue sample test) at The First Affiliated Hospital of Sun Yat-sen University Who may not be able to join: - You are under 14 years old - You do not wish to sign a written consent form agreeing...

**Who might be able to join this trial:** - You are 5 years old or older - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) using specific 2019 medical guidelines, and your disease is still moderately to severely active despite taking high-dose steroids, hydroxychloroquine,...

**Who might be able to join this trial:** **For everyone in the trial:** - You have been diagnosed with one of the following conditions: Systemic Lupus Erythematosus without kidney involvement (SLE-Non-renal), Lupus with kidney involvement (Lupus Nephritis), or Systemic Sclerosis/Diffuse Cutaneous Systemic Sclerosis...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) based on recognised medical classification guidelines - You have had a positive result on certain blood tests related to lupus (ANA, anti-dsDNA, or anti-Smith), either...

**Who might be able to join this trial:** - You (or your guardian) must be willing and able to sign a consent form approved by an ethics committee before any screening begins - You must be 18 years of age or older (any gender) - You must have been formally diagnosed with systemic lupus erythematosus (SLE, or lupus) ac...

Who might be able to join this trial: - People who have signed a consent form agreeing to take part in this extension study before it begins. - People who previously took part in the SIRIUS-LN core study and completed the full treatment period up to Week 144, whether that was on the blinded or open-label treatment. Wh...

Who might be able to join this trial: - People who have been diagnosed with systemic lupus erythematosus (an autoimmune disease where the immune system attacks healthy tissue, sometimes called SLE or lupus) - People who have been diagnosed with systemic lupus erythematosus alongside a lung condition called interstitial...

**Who might be able to join this trial:** - People aged between 18 and 70 years old (inclusive), of any gender. - People who weigh at least 45 kg. - People who have been diagnosed with systemic lupus erythematosus (SLE — a long-term immune system condition) according to recognised medical classification criteria set i...

Who might be able to join this trial: - People who have been diagnosed with systemic lupus erythematosus (a chronic immune system disease, sometimes called SLE or lupus) based on recognised medical classification standards (either the 2012 SLICC criteria or the 2019 ACR/EULAR criteria) - People whose lupus symptoms fir...

**Who might be able to join this trial:** - People between 18 and 75 years old at the time of screening - People who have been formally diagnosed with systemic lupus erythematosus (SLE/lupus), meeting a specific number of recognised diagnostic criteria under established international classification systems - People wh...

**Who might be able to join this trial:** - You have been diagnosed with ankylosing spondylitis (AS), rheumatoid arthritis (RA), or lupus (SLE) - You are able to understand and sign a consent form agreeing to take part - If you are currently taking certain pain medications (such as anti-inflammatory drugs, tramadol, o...

Who might be able to join this trial: - You are 18 years of age or older - You have been diagnosed with systemic lupus erythematosus (SLE, a type of autoimmune disease) and have a specific form of kidney disease related to lupus (called lupus nephritis, Grade III, IV, or V), confirmed by a kidney biopsy - Your lupus di...

Who might be able to join this trial: - People aged 5 years or older. - People who have been diagnosed with systemic lupus erythematosus (SLE) using a recognised international classification system. - People who have had at least one specific lupus-related antibody detected in a blood test within the past 12 months or...

Who might be able to join this trial: - You are currently pregnant, or you were recently pregnant with a pregnancy outcome within the last year - You received at least one dose of the medication anifrolumab at some point during your pregnancy, or in the 16 weeks before you became pregnant Who may not be able to join:...

**Who might be able to join this trial:** - People who are older than 16 years of age - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) — a type of autoimmune disease — where the diagnosis meets the official guidelines set by two major international rheumatology organisations (ACR and EULAR) - Pe...

**Who might be able to join this trial:** - You are between 18 and 69 years old (inclusive), of any gender - Your bone marrow, blood clotting, heart, lungs, liver, and kidneys are working at an acceptable level as measured by specific lab tests (confirm with trial site for exact values) - You are not pregnant or breas...

**Who might be able to join this trial:** - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) by a rheumatologist or qualified rheumatology specialist. - People who are 18 years of age or older and meet the legal age requirements for consenting to research in the coun...

Who might be able to join this trial: **General requirements (all participants):** - A person must be willing to sign a consent form agreeing to take part in the trial. - A person must be between 18 and 60 years old (inclusive) at the time of signing the consent form, regardless of gender. - A person must not have had...

Who might be able to join this trial: - People aged between 18 and 70 years old (inclusive), of any gender - People who have been clinically diagnosed with Refractory Systemic Lupus Erythematosus (SLE)-related low platelet count (immune thrombocytopenia), confirmed by at least two blood tests showing very low platelet...

**Who might be able to join this trial:** - People aged 12 to 29 years old at the time of joining the trial. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) according to recognised international classification guidelines. - People whose blood tests show a positive ANA result above 1:80 and/or...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) for at least 12 weeks before the screening visit - Your lupus is considered moderately to severely active, based on a standard scoring system u...

**Who might be able to join this trial:** - You are able to understand and are willing to sign a consent form agreeing to take part - You are aged 18 to 75 years old (any gender) - Doctors expect you to live for more than 6 months - You have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) using the 2019 E...

"Who might be able to join this trial: - You must have already completed one of two specific earlier studies (called IM011074 or IM011132) for the full required treatment period. - Your doctor must believe that you are likely to benefit from continuing treatment with the study drug (deucravacitinib). - You must have re...

Who might be able to join this trial: - People aged 18 to 65 years old who have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) according to recognised 2019 classification guidelines - People whose lupus disease activity score (called SLEDAI) falls between 2 and 12, with some active clinical symptoms prese...

**Who might be able to join this trial:** - You have been diagnosed with lupus (SLE) according to recognized medical classification systems - Your lupus diagnosis was made 2 years ago or less - Your lupus is considered "non-organ-threatening," meaning it has not seriously affected your kidneys, brain, heart, lungs, ey...

Who might be able to join this trial: - People aged 18 or older who understand the study and are willing to sign a consent form agreeing to take part. - People diagnosed with Systemic Lupus Erythematosus (SLE) — a disease where the immune system attacks the body — according to recognised international diagnostic guidel...

**Who might be able to join this trial:** - You are 18 years old or older (any gender) - You have been diagnosed with Systemic Lupus Erythematosus (SLE or lupus) according to recognised medical guidelines - You have already tried several standard lupus treatments — including hydroxychloroquine, steroids at a certain d...

**Who might be able to join this trial:** - You are 18 years old or older, of any gender - You have been diagnosed with Systemic Lupus Erythematosus (SLE — a long-term immune system disease) using recognised medical guidelines, and your disease is currently active and has returned or not responded to previous treatmen...

**Who might be able to join this trial:** - You are between 6 and 18 years old (including those who are exactly 6 or 18) - You have been diagnosed with Systemic Lupus Erythematosus (SLE) based on recognised 2019 international guidelines - You have been diagnosed with an active, serious form of lupus affecting the kidn...

**Who might be able to join this trial:** - Adults aged 18 or older. - People who have been diagnosed with systemic lupus erythematosus (an autoimmune condition where the immune system attacks the body) according to recognised 2019 international classification standards. - People who have had a kidney biopsy within th...

Who might be able to join this trial: - You are an adult (18 years or older) - You are being cared for in the internal medicine department at Amiens University Hospital - You have been diagnosed with systemic lupus erythematosus (a condition where the immune system attacks the body's own tissues) - You have no history...

**Who might be able to join this trial:** - People aged 18 to 69 years old. - People who are willing to sign a consent form and follow all study requirements. - People whose blood counts, kidneys, liver, heart, and lungs are functioning at an adequate level. - People who agree to use acceptable methods of contraceptio...

**Who might be able to join this trial:** - You are 18 years of age or older and have been diagnosed with lupus by a doctor or healthcare provider - You are willing and able to give your own consent to take part - You can read and understand English well enough to answer the survey questions - You have access to a com...

Who might be able to join this trial: - People aged 5 years or older - People diagnosed with Systemic Lupus Erythematosus (SLE) according to recognised 2019 international classification standards, whose disease remains moderately to severely active despite at least 3 months of high-dose steroids, hydroxychloroquine, an...

**Who might be able to join this trial:** - Adults between 18 and 65 years old (any gender) who meet the 2019 international classification criteria for Systemic Lupus Erythematosus (SLE) - People in Cohort 1: Those with lupus that has affected the kidneys (lupus nephritis) that has not responded to treatment with ster...

**Who might be able to join this trial:** - People who have been diagnosed with systemic lupus erythematosus (SLE) based on recognised 2019 classification standards. - People whose lupus is currently rated as moderately to severely active, based on a standard disease activity scoring tool called SLEDAI-2000 (score abo...

**Who might be able to join this trial:** - You have been diagnosed with one of the following conditions: lupus (SLE), Sjögren's disease, scleroderma, rheumatoid arthritis, seronegative spondyloarthropathies, or systemic vasculitis (confirm with trial site for exact diagnosis requirements) - You are 18 years old or ol...

Who might be able to join this trial: - You have been diagnosed with Systemic Lupus Erythematosus (SLE) — an autoimmune disease — along with a related kidney condition called Lupus Nephritis (LN) - Your disease has either not responded to previous treatments or has come back after treatment (confirm with trial site for...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE) — a long-term immune system condition — at least 6 months before the screening visit, and a specific blood test at screening shows a positive result at a certain level (ANA ≥ 1:80). - You have SLE and a blood te...

Who might be able to join this trial: - People who are receiving their first-ever prescription of anifrolumab during the study period, with no prior history of being prescribed this medication - People for whom at least 12 months of medical history is available before the date of their first anifrolumab prescription -...

Who might be able to join this trial: - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, also known as lupus) based on at least one of three recognised sets of medical classification guidelines (from 1997, 2012, or 2019). - People who are 18 years of age or older. - People who are able to understa...

**Who might be able to join this trial:** - You are between 18 and 75 years old (inclusive) at the time of screening - You have been officially diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) for at least 24 weeks, confirmed using recognised medical guidelines - Certain specific lupus-related antibodies show u...

Who might be able to join this trial: - You are between 18 and 65 years old at the time of signing consent - You have been diagnosed with Systemic Lupus Erythematosus (SLE or Lupus) according to specific recognised medical guidelines (2019 EULAR/ACR criteria) - Your lupus is currently active and has been confirmed thro...

**Who might be able to join this trial:** - People who have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) according to a specific set of medical guidelines called the EULAR/ACR 2019 criteria - People whose lupus has not responded well enough to steroid medications and at least 2 different immune-suppres...

**Who might be able to join this trial:** - People who have been diagnosed with Systemic Lupus Erythematosus (SLE/lupus) according to recognised 2019 classification guidelines, with a diagnosis history of at least 6 months - People aged between 18 and 60 years old (inclusive) at the time of signing the consent form, w...

**Who might be able to join this trial:** - People who are willing to take part voluntarily, have been fully informed about the study, have signed a consent form, and are able to follow all study procedures. - People aged 18 to 75 years old (inclusive) at the time of signing the consent form, of any sex. - People who...

**Who might be able to join this trial:** - You fully understand what the trial involves, including its purpose and possible side effects, and are willing to sign a consent form agreeing to take part. - You are between 18 and 65 years old (inclusive) at the time of signing the consent form, and there are no restrictio...

Who might be able to join this trial: - You must be 18 years old or older. - Both men and women can take part. - You must have been diagnosed with Systemic Lupus Erythematosus (SLE, also known as lupus), confirmed using a specific set of internationally recognised medical guidelines called the SLICC criteria, or you ma...

**Who might be able to join this trial:** - You are a woman who has been continuously registered in the health database for at least 12 months before the start of your most recent pregnancy - You were diagnosed with lupus (SLE) before becoming pregnant - You have moderate or severe lupus (SLE) - **For the exposed grou...

**Who might be able to join this trial:** - People who are 18 years of age or older, of any gender, at the time of signing the consent form. - People whose blood test results show adequate bone marrow function, including sufficient white blood cell levels, a type of immune cell called neutrophils, and haemoglobin (con...

**Who might be able to join this trial:** - You are willing and able to sign a consent form agreeing to take part (or have a legal guardian sign on your behalf) - You are able and willing to follow the trial's schedule of visits and requirements - You are between 12 and 65 years old (inclusive) at the time of signing...

Who might be able to join this trial: - You are a patient who is just beginning treatment with LUPKYNIS (a medication) for a kidney condition caused by lupus (known as lupus nephritis) Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Important: Al...

Who might be able to join this trial: - You have been diagnosed with systemic lupus erythematosus (SLE, a type of autoimmune disease) using a specific set of recognised medical guidelines - You are 18 years old or older - You have been monitored or followed up for your condition for at least 6 months - Your lupus disea...

**Who might be able to join this trial:** - People who have been diagnosed with systemic lupus erythematosus (a type of autoimmune disease) according to recognised 2019 international classification standards - Men or women who are not pregnant, aged 18 or older - People who have been diagnosed with interstitial lung d...

**Who might be able to join this trial:** - Adults aged 18 to 69 years old. - People whose blood, liver, heart, and lung function are at adequate levels (as assessed by the trial site). - Women who could become pregnant must have a negative pregnancy test at the start of the trial, and all people who could become preg...

Who might be able to join this trial: - You have been diagnosed with lupus (SLE) based on recognised medical classification systems (ACR82 or SLICC 2012) - You are willing to give your consent to take part in the trial Who may not be able to join: - You are unable to read and understand the patient information provide...

**Who might be able to join this trial:** - Adults aged 18 or older who are able to give informed consent to take part. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) and meet the recognised classification criteria for this condition. - People with active SLE that is not primarily affecting t...

**Who might be able to join this trial:** - You are between 18 and 65 years old at the time of signing the consent form. - You are willing and able to give written consent to participate voluntarily. - You have been officially diagnosed with Systemic Lupus Erythematosus (SLE) for at least 6 months, confirmed by medica...

**Who might be able to join this trial:** - People who are 18 years of age or older, of any gender, at the time of signing the consent form. - People whose blood cell counts meet certain minimum levels — including white blood cells, a type of white blood cell called centrocytes, and haemoglobin — without having receiv...

**Who might be able to join this trial:** - People aged 18 to 70 years at the time of signing the consent form - People weighing at least 45 kg with a body mass index (BMI) between 18 and 30 - People who have been formally diagnosed with Systemic Lupus Erythematosus (SLE) meeting at least 4 specific classification cri...

Who might be able to join this trial: - The person is a woman of childbearing age who has been pregnant at least once - At least one pregnancy happened before being diagnosed with lupus (LES) - The lupus (LES) diagnosis was made after at least one pregnancy had already occurred - The lupus (LES) diagnosis meets specifi...

**Who might be able to join this trial:** - You are between 18 and 70 years old (male or female) - Your blood counts, liver, kidneys, blood clotting, and lungs are all functioning at a minimum acceptable level (confirm with trial site for specific values) - Your doctors expect you to live for more than 6 months - **If...

**Who might be able to join this trial:** - People aged 16 or older at the time of signing the consent form. - People who have been formally diagnosed with systemic lupus erythematosus (SLE) — a chronic autoimmune disease — according to recognised international classification guidelines. - People whose SLE has not res...

Who might be able to join this trial: - People who fully understand the trial's purpose and potential risks, are willing to take part, and have signed the informed consent form. - People aged 18 to 65 years (inclusive), of any gender. - People who have been diagnosed with systemic lupus erythematosus (SLE) using the 20...

**Who might be able to join this trial:** - You are able to understand what the study involves and are willing to sign a consent form. - You are male or female, aged between 18 and 70 years old at the time of signing the consent form. - Your body weight is between 40 and 90 kg (approximately 88 to 198 lbs). - You have...

Who might be able to join this trial: - People who fully understand what the trial involves and have signed a consent form agreeing to take part voluntarily. - People aged 18 to 65 years (inclusive) at the time of signing the consent form, of any gender. - People with Systemic Lupus Erythematosus (SLE) — a disease whe...

**Who might be able to join this trial:** - People who have been diagnosed with systemic lupus erythematosus (SLE, also called lupus) based on a specific set of internationally recognised medical guidelines from 2019. - People who have had a kidney biopsy (a small sample taken from the kidney) within the last 6 months...

**Who might be able to join this trial:** - You are between 18 and 75 years old at the time of signing the consent form - You have been diagnosed with Systemic Lupus Erythematosus (SLE) using recognised medical classification guidelines - Certain specific lupus-related antibodies have been found in your blood tests at...

Who might be able to join this trial: - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) using recognised diagnosis guidelines from 1997, 2012, or 2019 - People who have given written agreement to take part in the trial - People whose SLE is currently active and for w...

Who might be able to join this trial: - People aged between 18 and 60 years old. - People who have a confirmed diagnosis of Systemic Lupus Erythematosus (SLE or lupus), meeting a specific set of international diagnostic guidelines from 2019. - People whose medical records show certain positive blood test results, inclu...

**Who might be able to join this trial:** - People aged 18 to 80 years who have signed a consent form and are able to follow the study plan, in the trial doctor's judgment - People who have been formally diagnosed with Systemic Lupus Erythematosus (SLE, a disease where the immune system attacks the body) based on reco...

**Who might be able to join this trial:** - You are 18 years of age or older - You are biologically female - You have been diagnosed with Systemic Lupus Erythematosus (SLE/Lupus) according to specific 2019 classification guidelines (confirm with trial site) - Your immune-suppressing medications have not changed in the...

**Who might be able to join this trial:** - You are 5 years old or older (any gender may apply) - You have been diagnosed with lupus (SLE) using standard 2019 medical guidelines, and your disease is still moderate to severe despite at least 3 months of high-dose steroids, hydroxychloroquine, and at least 2 other stand...

**Who might be able to join this trial:** *Note: The Phase 1a portion of this trial (healthy volunteers) is no longer enrolling. The Phase 1b portion (patients with SLE or RA) is actively recruiting.* **General requirements for Phase 1b (all patients):** - Men and women between 18 and 75 years of age - People who are...

**Who might be able to join this trial:** - You have been diagnosed with cutaneous lupus (lupus affecting the skin) with a skin activity score of 8 or higher on a specific measurement scale called CLASI-A. - You have at least one active skin lesion of a specific type — either discoid lupus (DLE) or subacute cutaneous...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with systemic lupus erythematosus (a condition where the immune system attacks the body's own tissues) - You have health insurance coverage and are willing to take part and sign a consent form - (For a comparison group) You...

**Who might be able to join this trial:** - You are between 18 and 75 years old (any gender) - You have been officially diagnosed with systemic lupus erythematosus (SLE — a type of autoimmune disease) based on recognised medical guidelines - Your SLE has not responded well enough to at least 2 standard treatments trie...

**Who might be able to join this trial:** - Adults between 18 and 65 years old, of any gender - People who have been diagnosed with both lupus and fibromyalgia or chronic widespread pain by a licensed rheumatologist - People whose medications have remained the same and stable without changes **Who may not be able to j...

Who might be able to join this trial: - People aged 18 to 65 years old at the time of screening (both men and women) - People with a body mass index (BMI) of 18 or higher at the time of screening (BMI is a measure based on height and weight) - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, a typ...

Who might be able to join this trial: - People who are willing to take part and have given their full informed consent to join the study. - People aged between 18 and 70 years old (any gender). - People who were diagnosed with Systemic Lupus Erythematosus (SLE) — a long-term immune system condition — at least 24 weeks...

Who might be able to join this trial: - Adults aged 18 or older - People who have been diagnosed with Systemic Lupus Erythematosus (SLE or lupus) according to specific 2019 international classification guidelines, whose disease remains moderate to severe despite at least 3 months of high-dose steroid treatment and at l...

**Who might be able to join this trial:** - You are willing to sign a consent form and are able to attend all scheduled visits and follow the study procedures. - You are between 18 and 60 years old at the time of signing the consent form. - *(Part A only)* You are considered to be in good general health at the time of...

Who might be able to join this trial: - Adults between 18 and 70 years old who have been diagnosed with Systemic Lupus Erythematosus (lupus/SLE) according to recognised medical guidelines, and who have had a kidney biopsy confirming a specific type of lupus-related kidney disease (called lupus nephritis, class III, IV,...

**Who might be able to join this trial:** - You have agreed and signed a form giving your permission to take part in the study - You are 18 years old or older - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) based on recognised 2019 medical guidelines at the time of joinin...

**Who might be able to join this trial:** - People who are willing and able to give written consent to participate - People aged 18 to 70 years, of any sex - People whose organ function (such as liver and kidneys) meets the required health levels at screening - People who test positive for a protein called CD19 (a mark...

**Who might be able to join this trial:** - Adults aged 18 or older - People diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) according to specific 2019 international classification guidelines, whose disease is still moderately to severely active despite at least 3 months of high-dose st...

**Who might be able to join this trial:** - People whose vaccinations are current according to local health guidelines (a shingles vaccine is recommended but not required). - People who have a documented diagnosis of Discoid Lupus Erythematosus (DLE) — a form of lupus affecting the skin — and/or Subacute Cutaneous Lup...

**Who might be able to join this trial:** - People who have read and understood the study information and have signed a consent form agreeing to follow all study procedures - People aged 18 to 65 years old (inclusive) at the time of signing the consent form, of any gender - People who have had no widespread active inf...

**Who might be able to join this trial:** - People who have signed a written consent form to participate - People aged 14 to 65 years (inclusive), of any gender - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) according to a standard set of medical diagnostic guidel...

Who might be able to join this trial: - You have been officially diagnosed with systemic lupus erythematosus (a condition where the immune system attacks the body's own tissues) - Your lupus disease activity score (a standard measure called SLEDAI-2K) is 6 or higher, meaning your condition is considered at least modera...

**Who might be able to join this trial:** - You are 5 years old or older - You have been diagnosed with systemic lupus erythematosus (SLE, a type of autoimmune disease) confirmed using recognised 2019 medical guidelines - Your SLE has not responded well to previous treatments, or remains moderately to highly active (th...

**Who might be able to join this trial:** - Your vaccinations are up to date based on the recommendations where you live (a specific shingles vaccine is encouraged but not required). - You have been diagnosed with Discoid Lupus Erythematosus (a type of lupus that affects the skin, causing scarring rashes) and/or Subac...

**Who might be able to join this trial:** - Adults between 18 and 70 years old (inclusive), of any sex - People who have previously been treated with a single-target CD19 or BCMA therapy that did not work, and who have waited at least 6 months since that last treatment - People diagnosed with one of the following cond...

**Who might be able to join this trial:** - People who are able to understand the study requirements, are willing to take part voluntarily, and have signed the consent form before any study procedures begin. - People aged 18 to 74 years old at the time of screening, of any gender. - People whose blood tests show certa...

**Who might be able to join this trial:** - Adults between 18 and 60 years of age - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) according to a specific set of medical guidelines from 2019 (known as the EULAR/ACR classification criteria) - People who have at least one skin-related symptom or r...

Who might be able to join this trial: - People aged 5 years or older, of any gender. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) according to specific 2019 international classification standards. - People whose SLE remains moderately to severely active despite...

Who might be able to join this trial: - You have agreed to take part in this long-term follow-up study by signing a consent form. - You have previously received at least one treatment infusion of a therapy called KYV-101 as part of an earlier related clinical study. Who may not be able to join: - There are no specific...

**Who might be able to join this trial:** - Be between 18 and 80 years old - Have been diagnosed with systemic lupus erythematosus (SLE/lupus) based on recognised international diagnostic guidelines - Have a specific blood test result showing a positive ANA reading of 1:80 or higher, or a positive anti-dsDNA result (ty...

**Who might be able to join this trial:** - You are 18 years old or older at the time of signing the consent form - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) - Your doctor has prescribed you a medication called anifrolumab (given as an injection under the skin), follo...

Who might be able to join this trial: - You must meet a specific set of medical guidelines (set by the American College of Rheumatology) used to diagnose your condition (confirm with trial site) - Your condition must have first started before you were 18 years old Who may not be able to join: - People who have had can...

Who might be able to join this trial: - People aged 18 to 70 years old, of any sex - People who have been formally diagnosed with Systemic Lupus Erythematosus (SLE/lupus) by a rheumatologist - People whose blood test results at the screening visit show certain lupus-related markers (ANA, Anti-dsDNA, or Anti-Smith antib...

Who might be able to join this trial: - People aged 16 to 55 years, either male or female - People who have been diagnosed with systemic lupus erythematosus (SLE), a disease where the immune system attacks the body's own tissues, based on a specific set of international diagnostic guidelines, with a score of 10 or hig...

**Who might be able to join this trial:** - People aged 18 to 65 years at the time of screening, of any gender. - People who have been diagnosed with systemic lupus erythematosus (SLE) according to the 2019 EULAR/ACR classification criteria. - People whose SLE has not responded to standard treatments, including steroi...

**Who might be able to join this trial:** - People who are willing to take part voluntarily and sign a consent form - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) according to 2019 international classification guidelines, and whose condition has not responded well enough to standard treatment...

**Who might be able to join this trial:** - People aged 5 years or older, of any gender - People (or their legal guardian) who agree to take part and sign a consent form after being fully informed about the trial - People whose blood tests confirm that their B cells (a type of immune cell) carry a marker called CD19,...

**Who might be able to join this trial:** - People who are willing to take part in the study and are able to sign a consent form, attend all required visits, and complete all study-related procedures. - People who have been diagnosed with Systemic Lupus Erythematosus (SLE) — a long-term immune system condition — for a...

**Who might be able to join this trial:** - Adults aged 18 to 75 years at the time of signing the consent form (the minimum age may vary in some countries based on local rules) - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) for at least 6 months before joining, a...

Who might be able to join this trial: **Group 1 – Rheumatoid Arthritis (RA):** - Adults aged 18 or older - People currently being treated and monitored at a participating department at University Hospital of Montpellier (UHM) for an autoimmune condition - People with a confirmed diagnosis of rheumatoid arthritis based...

Who might be able to join this trial: - People aged 18 to 70 years old at the time of giving consent. - People who have been diagnosed with systemic lupus erythematosus (SLE) using a recognised 2019 international classification system, with a score meeting the required threshold. - People whose lupus is currently activ...

**Who might be able to join this trial:** - People who are willing to give their informed consent, understand what the study involves, and are able to complete all trial procedures - People aged 18 to 70 years, of any gender - People who have a sufficient level of a specific type of immune cell (CD19-positive B cells)...

**Who might be able to join this trial:** - You have been diagnosed with Systemic Lupus Erythematosus (SLE, a type of autoimmune disease) for at least 6 months, confirmed using standard medical guidelines **Who may not be able to join:** - You are pregnant, breastfeeding, planning to become pregnant during the study,...

**Who might be able to join this trial:** - You are between 18 and 75 years old at the time of screening - You have a minimum level of certain immune cells (B-cells) in your blood at the start of the trial (confirm with trial site) **If you have Lupus (SLE), you may also need to meet these requirements:** - You have...

Who might be able to join this trial: - Adults between 18 and 75 years old - People who have been diagnosed with lupus nephritis (a form of kidney disease linked to lupus) confirmed by a kidney biopsy, classified as class III, IV, III/V, or IV/V under a standard medical classification system - People whose urine test s...

**Who might be able to join this trial:** - People between 18 and 75 years old, of any gender - People who have been diagnosed with active lupus (SLE) that has not responded well to previous treatments, confirmed using recognised medical criteria for at least 24 weeks, with a high disease activity score at the time of...

**Who might be able to join this trial:** - People who are able to give voluntary written consent to participate and follow the study requirements - Adults aged 18 to 60 years at the time of screening - People diagnosed with Systemic Lupus Erythematosus (SLE, a chronic immune system disease) that has come back or not...

**Who might be able to join this trial:** - You are 50 years of age or older at the time of signing up - You have been diagnosed with lupus (SLE) based on recognised medical criteria (confirm with trial site) - Your lupus is currently stable and not in a severe flare - You have been taking one or more lupus medications...

**Who might be able to join this trial:** - You are between 18 and 64 years old - You have been diagnosed with systemic lupus erythematosus (SLE, also known as lupus) based on recognised medical guidelines - You have a low platelet count (a type of blood cell that helps with clotting) — either below a certain level, or...

Who might be able to join this trial: - You are 18 years old or older - You have been diagnosed with systemic lupus erythematosus (lupus/SLE) based on recognised medical criteria - You are already receiving regular medical care at Oslo University Hospital or another centre taking part in this trial - You are able to un...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with a specific type of kidney disease called lupus nephritis (class III, IV, III/IV, or III/V), confirmed by a kidney biopsy - People whose kidneys are functioning at a moderate level or above, based on a specific kidney function b...

**Who might be able to join this trial:** - Children and teenagers aged 6 years up to (but not including) 18 years, who weigh at least 20 kg - People who have been diagnosed with Systemic Lupus Erythematosus (SLE, also known as lupus) according to specific 2019 international medical guidelines - People who have had a...