Early Phase 1 Prostate Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have a confirmed diagnosis of advanced or metastatic breast cancer or prostate cancer (confirmed by a tissue or cell sample test)
• You are generally well enough to carry out light activity and care for yourself (your doctor will assess this using a standard scale called ECOG 0–1)
• Your cancer has been shown to be getting worse within the last 30 days before signing up for the study
• You have already tried the standard available treatments for your cancer in its advanced stage
• You have at least one tumour that can be seen on a scan and measures at least 1 cm in size
• Your blood counts, liver, and kidney function are within acceptable levels (your doctor will check this with blood tests)
• You are able to lie still for up to 60 minutes during a scan
• You are willing and able to understand and sign a consent form agreeing to take part
• You may optionally provide stored or fresh tumour tissue samples for additional testing, but this is not required to join

Who may not be able to join:

• You have a known allergy or sensitivity to the study's imaging substances (DOTA-STR-17126)
• You have serious heart failure classified as Class 3 or 4 (confirm with trial site)
• You have an abnormal heart rhythm reading on an ECG, or a history of a condition called long QT syndrome (confirm with trial site)
• You have had significant bleeding (such as from the stomach or brain) within the two weeks before joining the trial
• You are pregnant or currently breastfeeding
• You are a woman who could become pregnant, or a man whose partner could become pregnant, and you are not willing to use reliable contraception during the trial and for at least 6 months after receiving the treatment
• Sexually active male participants must use a condom during intercourse while in the trial and for 4 months after finishing treatment, including men who have had a vasectomy
• You have a medical condition that prevents you from fully emptying your bladder (though exceptions may be considered on a case-by-case basis)
• You have had major surgery (involving general anaesthetic and a significant cut) within the last 30 days, or are expected to have such surgery within the next 6 weeks
• You have another active cancer that has required treatment within the past 2 years
• You have had a different cancer diagnosis within the last 3 years (some exceptions may apply for certain skin, cervical, bladder, or thyroid cancers that are considered cured — confirm with trial site)
• You have an active, uncontrolled infection (bacterial, viral, or fungal) that requires medication, within the last 30 days
• You have a mental health or personal situation that would make it difficult to follow the study requirements
• You weigh more than 160 kg (350 lbs), as the scanning equipment has a weight limit
• You have previously received any treatment that specifically targets the same protein (GRPR) that this study is investigating
• You have recently received certain anti-cancer treatments (such as chemotherapy, radiation, immunotherapy, or others) and not enough time has passed since your last dose — the required waiting time varies depending on the type of treatment (confirm with trial site)
• You have a history of an inflammatory condition (such as an autoimmune or granulomatous disease) that could affect how the scan results are interpreted, particularly one affecting the chest or abdomen
• You still have significant side effects from a previous cancer treatment that have not yet returned to a mild level or your normal baseline (hair loss is an exception)

Important: Always verify eligibility with the trial site directly before applying.