Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given written consent to participate (or whose legal representative has done so on their behalf)
• People who agree to allow stored tumour tissue samples from their diagnosis to be used in the study
• People aged 18 or older
• People whose general physical functioning meets a certain level of activity (known as ECOG score of 3 or below — confirm with trial site)
• People who have been diagnosed with a specific type of blood cancer called Acute Myeloid Leukaemia (AML), confirmed through laboratory testing
• People whose AML has come back or has not responded to previous treatment — specifically, at least one prior treatment for those with higher-risk disease, or at least two prior treatments for those with lower- or moderate-risk disease
• People who have enough cancer cells available in their bone marrow or blood for specialised laboratory testing (either through a blood sample with enough circulating cancer cells, a bone marrow sample with enough cancer cells present, bone marrow biopsy fluid if a standard sample cannot be obtained, or a sample from disease outside the bone marrow if accessible)
• People whose life expectancy is expected to be greater than 100 days
• People who have recovered from most side effects of previous cancer treatment (minor ongoing side effects at a low level, and hair loss, are acceptable)

Who may not be able to join:

• People who have a specific chromosomal change called t(15;17), or a subtype of AML known as acute promyelocytic leukaemia (APL or FAB M3)
• People with active cancer in the central nervous system (brain or spinal cord) that has not been treated or is not responding to treatment
• People with active graft versus host disease (a complication that can occur after a bone marrow or stem cell transplant)
• People with unstable heart conditions, including a heart attack within the past 6 months, uncontrolled irregular heart rhythm (atrial fibrillation), or uncontrolled high blood pressure
• People with a serious uncontrolled illness
• People with an uncontrolled active infection
• People who are pregnant or breastfeeding
• People with another serious condition or active cancer that the trial doctor believes would make participation unsafe
• People who, in the trial doctor's judgement, may have difficulty following all study procedures for any reason
• People who are planning to receive a live vaccine during the study period

Important: Always verify eligibility with the trial site directly before applying.