Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years, of any gender
• People who have been diagnosed with a specific type of nasopharyngeal cancer (cancer at the back of the nose/throat) confirmed by laboratory testing, and whose cancer tests positive for a marker called EBER
• People whose cancer has not spread to distant parts of the body, confirmed to be at an early-to-intermediate stage using detailed scans and a standard cancer staging system
• People who are generally well enough to carry out daily activities with little or no limitation (confirm with trial site for exact fitness level required)
• People who have had a high-quality, contrast-enhanced MRI scan of the head and neck area before treatment, including specialised scan sequences, and who have at least one measurable area of cancer visible on imaging
• People who have had a specific blood test measuring a virus-related marker (called cfEBV DNA) taken before treatment begins
• People whose blood test results before treatment show healthy levels of red blood cells, white blood cells, and platelets, and whose liver and kidney function results are within an acceptable range, and who do not have severe hearing loss
• People who are able to understand what the study involves and who have agreed in writing to take part, either personally or through a legally authorised representative
• People who agree to allow the research team to use their clinical information, routine scan images, and leftover biological samples (such as blood samples and tissue slides) for research purposes
• People whose major organs are functioning adequately, except for any effects directly caused by the nasopharyngeal cancer itself
• People who are expected to reliably attend follow-up appointments over the long term and have consistent means of communication with the research team

Who may not be able to join:

• People who did not have the cfEBV DNA blood test taken before treatment, or who are missing key information needed for a specific risk calculation used in this study (such as age, cancer stage, a particular enzyme level, or scan findings about the tumour)
• People whose cancer has already spread to distant parts of the body (known as M1 or metastatic disease)
• People who have had another type of cancer, unless it was a non-melanoma skin cancer or a very early cervical cancer that was fully treated and has shown no signs of returning for more than 5 years
• People who are pregnant or breastfeeding, or people who are capable of having children and are unwilling to use effective contraception during the study period
• People who are currently taking part in another clinical trial that involves an experimental drug or medical device
• People who have serious or poorly controlled health conditions, which may include: a heart attack in the past 6 months, serious heart rhythm problems, a recent severe stroke, an active stomach or bowel ulcer, uncontrolled mental health conditions, uncontrolled diabetes, an active autoimmune disease, long-term use of medicines that suppress the immune system, a serious active infection requiring treatment, a known history of HIV, active hepatitis B with a high viral load, or hepatitis C with abnormal viral levels
• People whose personal, social, geographic, or mental health circumstances would, in the trial team's judgment, make it impossible to attend regular follow-up visits and assessments

Important: Always verify eligibility with the trial site directly before applying.