Interstitial Lung Disease Trial, Not Yet Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• COPD group: Adults aged 40 or older who either have a confirmed COPD diagnosis (based on symptoms like breathlessness, long-term cough, or mucus production, plus breathing test results showing a persistent airflow problem) or who have symptoms suggesting possible COPD based on a specific questionnaire score, but whose breathing tests have not yet confirmed airflow problems.
• COPD group: Must not have had a COPD flare-up (worsening of symptoms) in the past month.
• Asthma group: People aged 3 or older who either have a confirmed asthma diagnosis (with recurring symptoms like wheezing, breathlessness, chest tightness, or cough that come and go, plus breathing tests showing variable airflow) or who have ongoing breathing symptoms but no confirmed airflow changes yet.
• Healthy volunteers: People aged 3 or older with no breathing symptoms, no serious heart or lung disease history, no respiratory infection in the past 4 weeks, who have never smoked or smoked fewer than 100 cigarettes in their lifetime, no harmful workplace exposure, normal chest exam and chest scan results within the past year, and a body weight in the normal range (BMI 18.5–24.9).
• Bronchiectasis group: People aged 3 or older with a history consistent with bronchiectasis confirmed by a CT scan, and no other current lung conditions.
• Interstitial lung disease (ILD) group: People aged 3 or older with scarring/fibrotic lung disease confirmed by a specific type of CT scan (HRCT) or lung tissue sample, affecting more than 10% of the lung, and no other current lung conditions.
• Upper airway obstruction group: People aged 3 or older with a history of conditions that can narrow the upper airway (such as injury, intubation, tumours, or foreign object inhalation), whose main symptoms are breathlessness that worsens with activity or changes with body position, whose breathing tests show a characteristic blocked airflow pattern, and who have at least one scan or scope test confirming airway narrowing.

Who may not be able to join:

• People who have medical reasons that make breathing tests (oscillometry or spirometry) unsafe, such as severe uncontrolled breathlessness, active respiratory infection flare-up, uncontrolled epilepsy, mouth or face problems preventing a proper seal on the mouthpiece, a perforated eardrum, a need for constant oxygen, a feeding tube in place, a permanent tracheotomy opening, or being on a breathing machine that cannot be paused.
• People who cannot safely do spirometry (a standard breathing test) due to recent serious heart problems, uncontrolled high blood pressure, aortic aneurysm, severe overactive thyroid, a heart rate above 120 beats per minute, a perforated eardrum, or other active respiratory infections.
• People who have other lung conditions that could affect breathing test results, such as lung cancer, pneumonia, active tuberculosis, or a blood clot in the lungs.
• People who have recently had surgery that could affect breathing test results, such as open chest surgery or surgery for fluid around the lungs.
• People who are unable to cooperate well enough during breathing tests to meet the required quality standards.
• Women who are currently breastfeeding.
• People the research team believes are unlikely to follow the study procedures and requirements.

Important: Always verify eligibility with the trial site directly before applying.